Title:
GRAPHENE CHIP FOR SPECIFICALLY CAPTURING CIRCULATING TUMOR CELLS IN WHOLE BLOOD AND MANUFACTURING METHOD AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2018/133617
Kind Code:
A1
Abstract:
The present invention provides a graphene chip for specifically capturing circulating tumor cells in whole blood and a manufacturing method and application thereof. The manufacture of the graphene chip comprises: using a single crystal structure having a three-dimensional geometric shape obtained by recrystallization of inorganic compound powder as a template; introducing a carbon source and causing the same to undergo high temperature pyrolysis to obtain a solution of graphene particles having a three-dimensional structure; performing suction filtration or spin coating of the solution to obtain a graphene substrate having a three-dimensional geometric micro-nano structure on a surface thereof; and modifying the graphene substrate with a specific recognition antibody to obtain the graphene chip that specifically captures circulating tumor cells. The antibody-modified, three-dimensional geometric micro-nano structured graphene chip can significantly improve the efficiency of capturing circulating tumor cells.
Inventors:
FAN JUNBING (CN)
WANG SHUTAO (CN)
JIANG LEI (CN)
LI GUANNAN (CN)
WANG SHUTAO (CN)
JIANG LEI (CN)
LI GUANNAN (CN)
Application Number:
PCT/CN2017/117495
Publication Date:
July 26, 2018
Filing Date:
December 20, 2017
Export Citation:
Assignee:
BEIJING SCITECH NANOTECHNOLOGY COMPANY LTD (CN)
International Classes:
G01N33/574
Foreign References:
| CN105771015A | 2016-07-20 | |||
| CN104714013A | 2015-06-17 |
Other References:
HYEUN JOONG YOONL ET AL.: "Sensitive Capture of Circulating Tumour Cells by Functionalized Graphene Oxide Nanosheets", NATURE NANOTECHNOLOGY, vol. 8, 29 September 2013 (2013-09-29), XP055504561
SHENGYAN YIN ET AL.: "Three-Dimensional Graphene Composite Macroscopic Structures for Capture of Cancer Cells.", ADV. MATER. INTERFACES., 13 February 2014 (2014-02-13), XP055504566
SHENGYAN YIN ET AL.: "Three-Dimensional Graphene Composite Macroscopic Structures for Capture of Cancer Cells.", ADV. MATER. INTERFACES., 13 February 2014 (2014-02-13), XP055504566
Attorney, Agent or Firm:
BEIJING ENHO LAW FIRM (CN)
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