Title:
GRNF4, A GDNF-RELATED NEUROTROPHIC FACTOR
Document Type and Number:
WIPO Patent Application WO2000034475
Kind Code:
A9
Abstract:
The present invention relates to molecules referred to as GDNF-related neurotrophic factor 4 (GRNF4). The present invention involves the cloning, expression, characterization and use of GRNF4. Polynucleotide molecules and amino acid sequences are described for GRNF4. GRNF4 is 35 % identical to glial cell line-derived neurotrophic factor and 46 % identical to neurturin. GRNF4 binds to GFR alpha -3 which is a receptor of the GFR alpha family exclusively expressed in the peripheral sensory and sympathetic nervous systems.
Inventors:
SIMONET WILLIAM SCOTT (US)
ASUNCION FRANKLIN J (US)
MIN HOSUNG (US)
JING SHUQIAN (US)
ASUNCION FRANKLIN J (US)
MIN HOSUNG (US)
JING SHUQIAN (US)
Application Number:
PCT/US1999/028975
Publication Date:
August 29, 2002
Filing Date:
December 08, 1999
Export Citation:
Assignee:
AMGEN INC (US)
SIMONET WILLIAM SCOTT (US)
ASUNCION FRANKLIN J (US)
MIN HOSUNG (US)
JING SHUQIAN (US)
SIMONET WILLIAM SCOTT (US)
ASUNCION FRANKLIN J (US)
MIN HOSUNG (US)
JING SHUQIAN (US)
International Classes:
G01N33/53; A61K38/00; A61P3/14; A61P19/10; A61P25/02; A61P25/16; A61P25/28; C07K14/475; C07K14/48; C07K16/22; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/09; C12N15/12; C12P21/02; C12P21/08; G01N33/577; (IPC1-7): C12N15/12; A61K35/12; A61K38/18; C07K14/475; C07K16/22; C12N5/10; C12N5/12
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