Title:
GROUP 2 INNATE LYMPHOID CELL GROWTH INHIBITOR
Document Type and Number:
WIPO Patent Application WO/2023/048277
Kind Code:
A1
Abstract:
Provided is a group 2 innate lymphoid cell growth inhibitor containing MAIT cells.
Inventors:
SHIMIZU YASUO (JP)
WAKAO HIROSHI (JP)
SUGIMOTO CHIE (JP)
WAKAO HIROSHI (JP)
SUGIMOTO CHIE (JP)
Application Number:
PCT/JP2022/035655
Publication Date:
March 30, 2023
Filing Date:
September 26, 2022
Export Citation:
Assignee:
DOKKYO MEDICAL UNIV (JP)
International Classes:
A61K35/17; A01K67/027; A61P1/04; A61P1/16; A61P9/00; A61P9/10; A61P11/00; A61P11/06; A61P13/10; A61P17/00; A61P21/00; A61P29/00; A61P31/12; A61P31/16; A61P33/00; A61P35/00; A61P37/06; A61P37/08; C12N5/0783; C12Q1/02
Other References:
PARK HAN-KI, CHOI YOUNGWOO, LEE DONG-HYUN, KIM SUJEONG, LEE JONG-MYUNG, CHOI SAE WON, LEE HEE-RA, RHO MINA, PARK HAE-SIM: "Altered gut microbiota by azithromycin attenuates airway inflammation in allergic asthma", JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, vol. 145, no. 5, 1 May 2020 (2020-05-01), AMSTERDAM, NL , pages 1469 - 1473, XP093052854, ISSN: 0091-6749, DOI: 10.1016/j.jaci.2020.01.044
GOH MURAYAMA, ASAKO CHIBA , HIROFUMI AMANO , KEN YAMAJI , NAOTO TAMURA, SACHIKO MIYAKE: "1749 The role of mucosal-associated invariant T (MAIT) cells in lupus dermatitis", ARTHRITIS AND RHEUMATOLOGY, vol. 68, no. Supplement 10, pages 2199 - 2200, XP093053417
RUIJING X , MENGJUN W , XIAOLING Z , SHU P , MEI W , YINGCHENG Z , YULING H , JINQUAN T: "Jα33+ MAIT cells play a protective role in TNBS induced intestinal inflammation", HEPATO-GASTROENTEROLOGY, vol. 59, no. 115, 1 May 2012 (2012-05-01), pages 762 - 767, XP009544850, DOI: 10.5754/hge11432
CHANDRA SHILPI, WINGENDER GERHARD, GREENBAUM JASON A., KHURANA ARCHANA, GHOLAMI AMIN M., GANESAN ANUSHA-PREETHI, ROSENBACH MICHAEL: "Development of Asthma in Inner-City Children: Possible Roles of MAIT Cells and Variation in the Home Environment", THE JOURNAL OF IMMUNOLOGY, vol. 200, no. 6, 15 March 2018 (2018-03-15), US , pages 1995 - 2003, XP093053423, ISSN: 0022-1767, DOI: 10.4049/jimmunol.1701525
SHIMIZU, YASUO: "PP604: MAIT Cells attenuate Eosinophilic Airway Inflammation Induced by Alternaria alternata", ANNALS OF THE JAPANESE RESPIRATORY SOCIETY, vol. 11, no. Suppl., 1 April 2022 (2022-04-01) - 24 April 2022 (2022-04-24), pages 282, XP009545061, ISSN: 2186-5876
H. SASANO, N. HARADA, Y. SANDHU, Y. TANABE, S. HARADA, T. WATANABE, Y. SATO, T.NISHIMAKI, S. ABE, S. UEDA, A. GOTO, T. TAKESHIGE, : "Mucosal Associated Invariant T Cells May Have Any Protective Role Against Type 2 Airway Inflammation in OVA-Induced Murine Asthma Model", AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, vol. 205, 1 May 2022 (2022-05-01), pages A3762 - A3762, XP093053430
CROXFORD J LUDOVIC, MIYAKE SACHIKO, HUANG YI-YING, SHIMAMURA MICHIO, YAMAMURA TAKASHI: "Invariant Vα19i T cells regulate autoimmune inflammation", NATURE IMMULOGY, vol. 7, no. 9, 15 November 2022 (2022-11-15), New York , pages 987 - 994, XP093053445, ISSN: 1529-2908, DOI: 10.1038/ni1370
AYAKO ISHIMORI, NORIHIRO HARADA, ASAKO CHIBA, SONOKO HARADA, KEI MATSUNO, FUMIHIKO MAKINO, JUN ITO, SHOICHIRO OHTA, JUNYA ONO, RYO: "Circulating activated innate lymphoid cells and mucosal-associated invariant T cells are associated with airflow limitation in patients with asthma", ALLERGOLOGY INTERNATIONAL, vol. 66, no. 2, 1 January 2017 (2017-01-01), pages 302 - 309, XP093053447, ISSN: 1323-8930, DOI: 10.1016/j.alit.2016.07.005
CHIBA, ASAKO: "Understanding the relationship between basic immunology and rheumatic diseases. Innate lymphoid MAIT cells and autoimmunity", RHEUMATOLOGY, vol. 58, no. 5, 1 January 2017 (2017-01-01), JP , pages 474 - 479, XP009544988, ISSN: 0915-227X
HARADA, NORIHIRO: "New developments in immunology and respiratory diseases. Respiratory diseases and MAIT cells", THE LUNG PERSPECTIVES, vol. 25, no. 4, 1 January 2017 (2017-01-01), JP , pages 383 - 386, XP009545057, ISSN: 0919-5742
GOH MURAYAMA, ASAKO CHIBA , HIROFUMI AMANO , KEN YAMAJI , NAOTO TAMURA, SACHIKO MIYAKE: "1749 The role of mucosal-associated invariant T (MAIT) cells in lupus dermatitis", ARTHRITIS AND RHEUMATOLOGY, vol. 68, no. Supplement 10, pages 2199 - 2200, XP093053417
RUIJING X , MENGJUN W , XIAOLING Z , SHU P , MEI W , YINGCHENG Z , YULING H , JINQUAN T: "Jα33+ MAIT cells play a protective role in TNBS induced intestinal inflammation", HEPATO-GASTROENTEROLOGY, vol. 59, no. 115, 1 May 2012 (2012-05-01), pages 762 - 767, XP009544850, DOI: 10.5754/hge11432
CHANDRA SHILPI, WINGENDER GERHARD, GREENBAUM JASON A., KHURANA ARCHANA, GHOLAMI AMIN M., GANESAN ANUSHA-PREETHI, ROSENBACH MICHAEL: "Development of Asthma in Inner-City Children: Possible Roles of MAIT Cells and Variation in the Home Environment", THE JOURNAL OF IMMUNOLOGY, vol. 200, no. 6, 15 March 2018 (2018-03-15), US , pages 1995 - 2003, XP093053423, ISSN: 0022-1767, DOI: 10.4049/jimmunol.1701525
SHIMIZU, YASUO: "PP604: MAIT Cells attenuate Eosinophilic Airway Inflammation Induced by Alternaria alternata", ANNALS OF THE JAPANESE RESPIRATORY SOCIETY, vol. 11, no. Suppl., 1 April 2022 (2022-04-01) - 24 April 2022 (2022-04-24), pages 282, XP009545061, ISSN: 2186-5876
H. SASANO, N. HARADA, Y. SANDHU, Y. TANABE, S. HARADA, T. WATANABE, Y. SATO, T.NISHIMAKI, S. ABE, S. UEDA, A. GOTO, T. TAKESHIGE, : "Mucosal Associated Invariant T Cells May Have Any Protective Role Against Type 2 Airway Inflammation in OVA-Induced Murine Asthma Model", AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, vol. 205, 1 May 2022 (2022-05-01), pages A3762 - A3762, XP093053430
CROXFORD J LUDOVIC, MIYAKE SACHIKO, HUANG YI-YING, SHIMAMURA MICHIO, YAMAMURA TAKASHI: "Invariant Vα19i T cells regulate autoimmune inflammation", NATURE IMMULOGY, vol. 7, no. 9, 15 November 2022 (2022-11-15), New York , pages 987 - 994, XP093053445, ISSN: 1529-2908, DOI: 10.1038/ni1370
AYAKO ISHIMORI, NORIHIRO HARADA, ASAKO CHIBA, SONOKO HARADA, KEI MATSUNO, FUMIHIKO MAKINO, JUN ITO, SHOICHIRO OHTA, JUNYA ONO, RYO: "Circulating activated innate lymphoid cells and mucosal-associated invariant T cells are associated with airflow limitation in patients with asthma", ALLERGOLOGY INTERNATIONAL, vol. 66, no. 2, 1 January 2017 (2017-01-01), pages 302 - 309, XP093053447, ISSN: 1323-8930, DOI: 10.1016/j.alit.2016.07.005
CHIBA, ASAKO: "Understanding the relationship between basic immunology and rheumatic diseases. Innate lymphoid MAIT cells and autoimmunity", RHEUMATOLOGY, vol. 58, no. 5, 1 January 2017 (2017-01-01), JP , pages 474 - 479, XP009544988, ISSN: 0915-227X
HARADA, NORIHIRO: "New developments in immunology and respiratory diseases. Respiratory diseases and MAIT cells", THE LUNG PERSPECTIVES, vol. 25, no. 4, 1 January 2017 (2017-01-01), JP , pages 383 - 386, XP009545057, ISSN: 0919-5742
Attorney, Agent or Firm:
KOBAYASHI Hiroshi et al. (JP)
Download PDF: