A GROUP OF AMINO SUBSTITUTED BENZOYL DERIVATIVES AND THEIR PREPARATION AND THEIR USE

Title:

A GROUP OF AMINO SUBSTITUTED BENZOYL DERIVATIVES AND THEIR PREPARATION AND THEIR USE

Document Type and Number:

WIPO Patent Application WO/2010/037271

Kind Code:

A1

Abstract:

A group of amino substituted benzoyl derivatives, their preparation and their use. The screening and research on an antiviral drug with hA3G/Vif as a target point proves that the 3-amino benzoyl derivatives not only have inhibiting the combined activity for the hA3G/Vif, but also have a function of inhibiting replication of viruses. The present invention provides the possible breakthrough progress for the problem of HIV drug resistance, thereby providing a novel clinical antiviral drug which has higher efficiency.

Inventors:

JIANG JIANDONG (CN)
YU LIYAN (CN)
CEN SHAN (CN)
LI ZHUORONG (CN)
LI YANPING (CN)
XU JIAN (CN)

Application Number:

PCT/CN2009/001094

Publication Date:

April 08, 2010

Filing Date:

September 28, 2009

Export Citation:

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Assignee:

INST MEDICINAL BIOTECHNOLOGY (CN)
JIANG JIANDONG (CN)
YU LIYAN (CN)
CEN SHAN (CN)
LI ZHUORONG (CN)
LI YANPING (CN)
XU JIAN (CN)

International Classes:

C07C237/44; A61K31/165; A61K31/21; A61K31/255; A61P31/12; C07C229/54; C07C233/12; C07C303/26; C07C307/02; C07C327/16; C07D239/52

Domestic Patent References:

WO2001002350A2

2001-01-11

Foreign References:

CN1944398A

2007-04-11

Other References: