Title:
GROUP OF ISOTOPE LABELING REAGENTS FOR AMINO/PHENOLIC HYDROXYL LABELING, AND SYNTHESIS METHOD THEREFOR
Document Type and Number:
WIPO Patent Application WO/2019/056251
Kind Code:
A1
Abstract:
The present invention relates to a group of isotope labeling reagents for amino/phenolic hydroxyl labeling, and a synthesis method therefor. In a synthesis process, a reagent (such as a homologue of 6-aminocaproic acid) carrying both amino and carboxyl is used as a raw material and reacts with isotope D-containing or 13C substituted iodomethane or formaldehyde, so as to convert the amino into quaternary ammonium and introduce an isotope on the iodomethane or the formaldehyde onto methyl of the quaternary ammonium. By selecting different D substituted or 13C substituted iodomethane and formaldehyde and regulating a reaction route, a series of products substituted by different isotopes can be obtained. The series of products further react with N-hydroxysuccinimide, so that the carboxyl thereof reacts with the hydroxyl of the N-hydroxysuccinimide to form an ester, so as to obtain a group of isotope labeling reagents capable of efficiently reacting with the amino or the phenolic hydroxyl.
Inventors:
WU MINGHUO (CN)
ZHAO KAIYONG (CN)
ZHOU HAO (CN)
LIU MIN (CN)
HU YUFENG (CN)
LIU LIFEN (CN)
ZHAO KAIYONG (CN)
ZHOU HAO (CN)
LIU MIN (CN)
HU YUFENG (CN)
LIU LIFEN (CN)
Application Number:
PCT/CN2017/102659
Publication Date:
March 28, 2019
Filing Date:
September 21, 2017
Export Citation:
Assignee:
UNIV DALIAN TECH (CN)
International Classes:
C07D295/24; C07B59/00
Domestic Patent References:
| WO2009114776A2 | 2009-09-17 |
Foreign References:
| CN106749402A | 2017-05-31 | |||
| CN102014929A | 2011-04-13 |
Download PDF: