Title:
GROWTH FACTOR BINDING CONSTRUCTS MATERIALS AND METHODS
Document Type and Number:
WIPO Patent Application WO2005087808
Kind Code:
A3
Abstract:
The present invention provides materials and methods for antagonizing the function of vascular endothelial growth factor receptors, platelet derived growth factor receptors and other receptors. Soluble binding constructs able to bind vascular endothelial growth factors, platelet derived growth factors, and other ligands are provided.
Inventors:
ALITALO KARI (FI)
JELTSCH MARKKU M (FI)
JELTSCH MARKKU M (FI)
Application Number:
PCT/US2005/007741
Publication Date:
December 01, 2005
Filing Date:
March 07, 2005
Export Citation:
Assignee:
LUDWIG INST CANCER RES (US)
LICENTIA LTD (FI)
ALITALO KARI (FI)
JELTSCH MARKKU M (FI)
LICENTIA LTD (FI)
ALITALO KARI (FI)
JELTSCH MARKKU M (FI)
International Classes:
C07K14/175; C07K14/71; C07K16/28; C07K19/00; A61K48/00; (IPC1-7): C07K14/71; C07K19/00; C07K14/475
Domestic Patent References:
| WO2002060950A2 | 2002-08-08 |
Other References:
KARPANEN T ET AL: "Vascular endothelial growth factor C promotes tumor lymphangiogenesis and intralymphatic tumor growth", CANCER RESEARCH, AMERICAN ASSOCIATION FOR CANCER RESEARCH, BALTIMORE, MD, US, vol. 61, 1 March 2001 (2001-03-01), pages 1786 - 1790, XP002966999, ISSN: 0008-5472
ACHEN M G ET AL: "VASCULAR ENDOTHELIAL GROWTH FACTOR D (VEGF-D) IS A LIGAND FOR THE TYROSINE KINASES VEGF RECEPTOR 2 (FLK1) AND VEGF RECEPTOR 3 (FLT4)", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE. WASHINGTON, US, vol. 95, no. 2, 20 January 1998 (1998-01-20), pages 548 - 553, XP002066364, ISSN: 0027-8424
TAMMELA T ET AL: "The biology of vascular endothelial growth factors", CARDIOVASCULAR RESEARCH, vol. 65, no. 3, 15 February 2005 (2005-02-15), pages 550 - 563, XP004722363, ISSN: 0008-6363
ACHEN M G ET AL: "VASCULAR ENDOTHELIAL GROWTH FACTOR D (VEGF-D) IS A LIGAND FOR THE TYROSINE KINASES VEGF RECEPTOR 2 (FLK1) AND VEGF RECEPTOR 3 (FLT4)", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE. WASHINGTON, US, vol. 95, no. 2, 20 January 1998 (1998-01-20), pages 548 - 553, XP002066364, ISSN: 0027-8424
TAMMELA T ET AL: "The biology of vascular endothelial growth factors", CARDIOVASCULAR RESEARCH, vol. 65, no. 3, 15 February 2005 (2005-02-15), pages 550 - 563, XP004722363, ISSN: 0008-6363
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