Title:
GUANIDINO-SUBSTITUTED QUINAZOLINONE COMPOUNDS AS MC4-R AGONISTS
Document Type and Number:
WIPO Patent Application WO2004112793
Kind Code:
B1
Abstract:
A variety of small molecule, guanidine-containing molecules capable of acting as MC4-R agonists are provided. The compounds are useful in treating MC4-R mediated diseases when administered to subjects. The compounds have the structure IA, IB, and IC where the values of the variables are defined herein.
Inventors:
BOYCE RUSTUM S (US)
AURRECOECHEA NATALIA (US)
CHU DANIEL (US)
SMITH AARON (US)
CONLEE CHRISTOPHER R (US)
THOMPSON BRIAN D (US)
DE ARMAS KUNTZ JUDITH (US)
MUSSO DAVID L (US)
BARVIAN KEVIN K (US)
THOMSON STEPHEN A (US)
SWAIN WILLIAM R (US)
DU KIEN S (US)
CHAUDER BRIAN A (US)
SPEAKE JASON D (US)
BISHOP MICHAEL J (US)
AURRECOECHEA NATALIA (US)
CHU DANIEL (US)
SMITH AARON (US)
CONLEE CHRISTOPHER R (US)
THOMPSON BRIAN D (US)
DE ARMAS KUNTZ JUDITH (US)
MUSSO DAVID L (US)
BARVIAN KEVIN K (US)
THOMSON STEPHEN A (US)
SWAIN WILLIAM R (US)
DU KIEN S (US)
CHAUDER BRIAN A (US)
SPEAKE JASON D (US)
BISHOP MICHAEL J (US)
Application Number:
PCT/US2004/015959
Publication Date:
March 10, 2005
Filing Date:
May 21, 2004
Export Citation:
Assignee:
CHIRON CORP (US)
GLAXOSMITHKLINE (US)
BOYCE RUSTUM S (US)
AURRECOECHEA NATALIA (US)
CHU DANIEL (US)
SMITH AARON (US)
CONLEE CHRISTOPHER R (US)
THOMPSON BRIAN D (US)
DE ARMAS KUNTZ JUDITH (US)
MUSSO DAVID L (US)
BARVIAN KEVIN K (US)
THOMSON STEPHEN A (US)
SWAIN WILLIAM R (US)
DU KIEN S (US)
CHAUDER BRIAN A (US)
SPEAKE JASON D (US)
BISHOP MICHAEL J (US)
GLAXOSMITHKLINE (US)
BOYCE RUSTUM S (US)
AURRECOECHEA NATALIA (US)
CHU DANIEL (US)
SMITH AARON (US)
CONLEE CHRISTOPHER R (US)
THOMPSON BRIAN D (US)
DE ARMAS KUNTZ JUDITH (US)
MUSSO DAVID L (US)
BARVIAN KEVIN K (US)
THOMSON STEPHEN A (US)
SWAIN WILLIAM R (US)
DU KIEN S (US)
CHAUDER BRIAN A (US)
SPEAKE JASON D (US)
BISHOP MICHAEL J (US)
International Classes:
A61K31/517; A61K31/519; A61K31/525; A61K31/53; A61P3/04; A61P3/10; C07D217/24; C07D239/91; C07D239/95; C07D239/96; C07D253/08; C07D401/04; C07D401/06; C07D401/12; C07D401/14; C07D403/04; C07D403/06; C07D403/12; C07D403/14; C07D405/12; C07D417/04; C07D417/14; C07D471/04; C07D475/02; C07D487/02; C07D487/04; (IPC1-7): A61K31/517; C07D239/91; C07D239/96; C07D403/12; A61P3/10; A61P3/04; C07D471/04; C07D403/06; C07D401/06; C07D401/04; C07D403/04; C07D239/95; C07D253/08; C07D217/24; C07D417/04
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