Title:
GUANYLHYDRAZONE DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/1995/023796
Kind Code:
A1
Abstract:
A guanylhydrazone derivative represented by general formula (I) and a salt thereof, useful for treating or preventing diseases caused by various complications of diabetes and aging by virtue of its activity of inhibiting the mailard reaction and various diseases caused by lipid peroxide production by virtue of its antioxidant activity. In formulae (I) and (II) R1 represents R4-A- (A being a single bond, alkylene or phenylalkylene; and R4 being a group of general formula (II)); R2 represents hydrogen, alkyl, phenyl, phenylalkyl, nitrogenous monocyclic hetero ring or alkyl substituted by nitrogenous monocyclic hetero ring, or R1 and R2 together with the carbon atom to which they are bonded represent cycloalkyl fused with R4; and R3 represents hydrogen, alkyl or acyl; provided when A represents phenylalkylene, the phenyl is bonded to the carbon atom to which R2 is bonded.
Inventors:
OHUCHIDA SHUICHI (JP)
HASEGAWA TOMOYUKI (JP)
KISHIMOTO KAZUO (JP)
HASEGAWA TOMOYUKI (JP)
KISHIMOTO KAZUO (JP)
Application Number:
PCT/JP1995/000294
Publication Date:
September 08, 1995
Filing Date:
February 27, 1995
Export Citation:
Assignee:
ONO PHARMACEUTICAL CO (JP)
OHUCHIDA SHUICHI (JP)
HASEGAWA TOMOYUKI (JP)
KISHIMOTO KAZUO (JP)
OHUCHIDA SHUICHI (JP)
HASEGAWA TOMOYUKI (JP)
KISHIMOTO KAZUO (JP)
International Classes:
C07D307/79; C07D307/80; C07D307/92; C07D311/72; C07D405/06; (IPC1-7): C07D307/79; C07D311/72; C07D405/06
Domestic Patent References:
| WO1992019236A1 | 1992-11-12 |
Other References:
EUR. J. MED. CHEM., 29, (1994), pages 223-32.
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