Title:
GUIDE RNA COMPLEMENTARY TO TRAC GENE AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/215982
Kind Code:
A1
Abstract:
The present invention relates to a guide RNA complementary to the TRAC gene and a use thereof. A guide RNA according to one aspect, a vector comprising same, and a TRAC gene editing composition, comprising the guide RNA and a Cas9 editor protein or a variant thereof, can effectively knock out the TRAC gene from the genome of a cell or an individual and thus can be useful in preventing or treating cancer through personalized medicine or precision medicine.
Inventors:
AN JAE HYUNG (KR)
HAN NA KYUNG (KR)
KIM DONG HEE (KR)
HAN NA KYUNG (KR)
KIM DONG HEE (KR)
Application Number:
PCT/KR2022/004810
Publication Date:
October 13, 2022
Filing Date:
April 04, 2022
Export Citation:
Assignee:
CELLENGENE INC (KR)
International Classes:
C12N15/113; A61K38/46; A61K48/00; A61P35/00; C12N9/22; C12N15/10; C12N15/63
Domestic Patent References:
| WO2020057668A1 | 2020-03-26 |
Foreign References:
| CN107746831B | 2019-04-23 | |||
| CN107828730B | 2019-04-30 | |||
| KR20170009865A | 2017-01-25 |
Other References:
TATIOSSIAN KRISTINA J., CLARK ROBERT D.E., HUANG CHUN, THORNTON MATTHEW E., GRUBBS BRENDAN H., CANNON PAULA M.: "Rational Selection of CRISPR-Cas9 Guide RNAs for Homology-Directed Genome Editing", MOLECULAR THERAPY, ELSEVIER INC., US, vol. 29, no. 3, 1 March 2021 (2021-03-01), US , pages 1057 - 1069, XP055976454, ISSN: 1525-0016, DOI: 10.1016/j.ymthe.2020.10.006
Attorney, Agent or Firm:
Y.P.LEE, MOCK & PARTNERS (KR)
Download PDF: