Title:
HUMAN IgM ANTIBODY INDUCING APOPTOSIS IN HIV-INFECTED CELLS AND REMEDY FOR HIV-INFECTION
Document Type and Number:
WIPO Patent Application WO/2004/003021
Kind Code:
A1
Abstract:
A monoclonal antibody falling within the category of human IgM which specifically recognizes HIV-infected cells and induces apoptosis is obtained. Using the obtained antibody, it is intended to provide a remedy for patients suffering from HIV-infection, which contains as the active ingredient a human IgM antibody capable of specifically reacting with HIV-infected cells, inducing apoptosis in the infected cells and thus disrupting the cells, etc.
Inventors:
OKADA HIDECHIKA (JP)
OKADA NORIKO (JP)
OKADA NORIKO (JP)
Application Number:
PCT/JP2003/008305
Publication Date:
January 08, 2004
Filing Date:
June 30, 2003
Export Citation:
Assignee:
OKADA HIDECHIKA (JP)
OKADA NORIKO (JP)
OKADA NORIKO (JP)
International Classes:
A61P31/18; C07K16/28; C12N15/13; (IPC1-7): C07K16/18; C12N5/16; C12N15/13; A61K39/395; A61P31/18
Domestic Patent References:
| WO1997022361A1 | 1997-06-26 | |||
| WO2000018426A1 | 2000-04-06 |
Foreign References:
| EP0510691A1 | 1992-10-28 |
Other References:
ITOH N. ET AL.: "The polypeptide encoded by the cDNA for human cell surface antigen fas can mediate apoptosis", CELL, vol. 66, no. 2, 1991, pages 233 - 243, XP000579691
YOSHIHIDE TSUJIMOTO: "Experimental Medicine", 25 March 1997, BIO MANUAL UP SERIES, article "Saishin apoptosis jikkenho", pages: 112 - 117, XP002973374
KLEIN R. ET AL.: "Expressed human immunoglobulin kappa genes and their hypermutation", EUR. J. IMMUNOL., vol. 23, 1993, pages 3248 - 3271, XP002971863
WANG X., STOLLAR B.D.: "Immunoglobulin VH gene expression in human aging", CLINICAL IMMUNOLOGY, vol. 93, no. 2, 1999, pages 132 - 142, XP002971864
"TIA-1 Cytotoxic cell marker", BECKMAN COULTER KABUSHIKI KAISHA, 1999, XP002973375, Retrieved from the Internet [retrieved on 20030801]
YOSHIHIDE TSUJIMOTO: "Experimental Medicine", 25 March 1997, BIO MANUAL UP SERIES, article "Saishin apoptosis jikkenho", pages: 112 - 117, XP002973374
KLEIN R. ET AL.: "Expressed human immunoglobulin kappa genes and their hypermutation", EUR. J. IMMUNOL., vol. 23, 1993, pages 3248 - 3271, XP002971863
WANG X., STOLLAR B.D.: "Immunoglobulin VH gene expression in human aging", CLINICAL IMMUNOLOGY, vol. 93, no. 2, 1999, pages 132 - 142, XP002971864
"TIA-1 Cytotoxic cell marker", BECKMAN COULTER KABUSHIKI KAISHA, 1999, XP002973375, Retrieved from the Internet
Attorney, Agent or Firm:
Hiroe, Takenori (Gifu-shi, Gifu, JP)
Download PDF: