Title:
HUMAN cDNAs ENCODING POLYPEPTIDES HAVING KINASE FUNCTIONS
Document Type and Number:
WIPO Patent Application WO2000008180
Kind Code:
A3
Abstract:
The invention is directed to purified and isolated human polypeptides having kinase function, the nucleic acids encoding such polypeptides, processes for production of recombinant forms of such polypeptides, antibodies generated against these polypeptides, fragmented peptides derived from these polypeptides, the use of such polypeptides and fragmented peptides in phosphorylation reactions and as molecular weight markers, the use of such polypeptides and fragmented peptides as controls for peptide fragmentation, the use of such polypeptides in screening assays, and kits comprising these reagents.
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Inventors:
VIRCA G DUKE (US)
BIRD TIMOTHY A (US)
ANDERSON DIRK M (US)
MARKEN JOHN S (US)
BIRD TIMOTHY A (US)
ANDERSON DIRK M (US)
MARKEN JOHN S (US)
Application Number:
PCT/US1999/017630
Publication Date:
June 29, 2000
Filing Date:
August 03, 1999
Export Citation:
Assignee:
IMMUNEX CORP (US)
VIRCA G DUKE (US)
BIRD TIMOTHY A (US)
ANDERSON DIRK M (US)
MARKEN JOHN S (US)
VIRCA G DUKE (US)
BIRD TIMOTHY A (US)
ANDERSON DIRK M (US)
MARKEN JOHN S (US)
International Classes:
C07H21/04; C07K16/40; C12N1/15; C12N1/19; G01N33/50; C12N1/21; C12N5/10; C12N9/12; C12N15/09; C12N15/55; C12P21/08; C12Q1/00; C12Q1/68; G01N33/15; G01N33/566; G01N33/577; (IPC1-7): C12N15/55; C12N9/12; C07K16/40; G01N33/50
Other References:
DEAK M. ET AL.: "Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38 and may mediate activation of CREB.", EMBO JOURNAL, vol. 17, no. 15, 3 August 1998 (1998-08-03), pages 4426 - 4441, XP002126284
MARRA M. ET AL.: "The WashU-HHMI Mouse Project.", EMBL DATABASE ENTRY MM1263730; ACCESSION NUMBER AA472165, 21 June 1997 (1997-06-21), XP002126285
PIERRAT B. ET AL.: "RSK-B, a novel ribosomal S6 kinase family member, is a CREB kinase under dominant control of p38(alpha) mitogen-activated protein kinase (p38(alpha)MAPK).", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 273, no. 45, 6 November 1998 (1998-11-06), pages 29661 - 29671, XP002126286
MARRA M. ET AL.: "The WashU-HHMI Mouse Project.", EMBL DATABASE ENTRY MM1263730; ACCESSION NUMBER AA472165, 21 June 1997 (1997-06-21), XP002126285
PIERRAT B. ET AL.: "RSK-B, a novel ribosomal S6 kinase family member, is a CREB kinase under dominant control of p38(alpha) mitogen-activated protein kinase (p38(alpha)MAPK).", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 273, no. 45, 6 November 1998 (1998-11-06), pages 29661 - 29671, XP002126286
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