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Title:
HAIR GROWTH PROMOTING AGENT CONTAINING 15,15-DIFLUOROPROSTAGLANDIN F2α DERIVATIVE AS ACTIVE INGREDIENT
Document Type and Number:
WIPO Patent Application WO/2010/027040
Kind Code:
A1
Abstract:
Provided is novel medicinal use of a 15,15-difluoroprostaglandin F2α derivative.  As a result of intensive studies in order to discover novel medicinal use of a 15,15-difluoroprostaglandin F2α derivative, it was found that, in Phase III clinical trial in Europe of tafluprost which is a 15,15-difluoroprostaglandin F2α derivative with patients with open-angle glaucoma or ocular hypertension, tafluprost has actions of growing eyelashes, making eyelashes thick and changing the color thereof, that is, has an effect of promoting the growth of hair (eyelashes).  Therefore, a 15,15-difluoroprostaglandin F2α derivative is useful as a hair growth promoting agent, and is expected to be useful as an active ingredient of a preventive or therapeutic agent for a disease associated with hair such as alopecia and a hair care product or a hair cosmetic product for hair regrowth, hair growth, increase in hair density, hair pilatory, etc.

Inventors:
ROPO AULI (FI)
Application Number:
PCT/JP2009/065462
Publication Date:
March 11, 2010
Filing Date:
September 04, 2009
Export Citation:
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Assignee:
SANTEN PHARMACEUTICAL CO LTD (JP)
ASAHI GLASS CO LTD (JP)
ROPO AULI (FI)
International Classes:
A61K31/5575; A61K8/69; A61P17/14; A61Q7/00
Domestic Patent References:
WO2007127639A22007-11-08
WO2009091765A12009-07-23
WO2001074315A22001-10-11
WO1998033497A11998-08-06
Foreign References:
JPH1171344A1999-03-16
JP2006306862A2006-11-09
JP2003528899A2003-09-30
JP2001511155A2001-08-07
EP0850926A21998-07-01
JP2004002462A2004-01-08
JPH10259179A1998-09-29
JP2002293771A2002-10-09
JP2003321442A2003-11-11
JP2006306862A2006-11-09
Other References:
LI NI ET AL.: "Travoprost compared with other prostaglandin analogues or timolol in patients with open-angle glaucoma or ocular hypertension: meta-analysis of randomized controlled trials.", CLINICAL & EXPERIMENTAL OPHTHALMOLOGY, vol. 34, no. 8, November 2006 (2006-11-01), pages 755 - 764, XP008142895
EGOROV EVGENY ET AL.: "Adjunctive use of tafluprost with timolol provides additive effects for reduction of intraocular pressure in patients with glaucoma.", EUROPEAN JOURNAL OF OPHTHALMOLOGY, vol. 19, no. 2, March 2009 (2009-03-01), pages 214 - 222, XP008142945
TAPUROSU (TOROKU SHOHYO) TENGAN'EKI 0.0015% TENPU BUNSHO, December 2008 (2008-12-01), XP008144519
See also references of EP 2338496A1
Attorney, Agent or Firm:
HIBI, Norihiko et al. (JP)
Norihiko Hibi (JP)
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