Title:
HAIR GROWTH-PROMOTING FUNCTION OF SMALL-SIZED STEM CELLS AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2016/006788
Kind Code:
A1
Abstract:
The present invention relates to a hair loss-preventing and hair growth-promoting composition, a producing method thereof, and use thereof, the composition containing, as an active ingredient, small-sized stem cells, and especially, small stem cells having diameters of 8 ㎛ or less, or a culture medium thereof, and the use of the composition being the use of the hair growth-promoting function retained by the small-sized stem cells having diameters of 8 ㎛ or less, the hair growth-promoting function markedly increasing the activation of resting hair follicle stem cells.
Inventors:
YANG YOON SUN (KR)
OH WONIL (KR)
LEE JANG YOUNG (KR)
CHOI SOO JIN (KR)
JEON HONG BAE (KR)
KIM JU-YEON (KR)
LIM HOON (KR)
OH WONIL (KR)
LEE JANG YOUNG (KR)
CHOI SOO JIN (KR)
JEON HONG BAE (KR)
KIM JU-YEON (KR)
LIM HOON (KR)
Application Number:
PCT/KR2015/002007
Publication Date:
January 14, 2016
Filing Date:
March 02, 2015
Export Citation:
Assignee:
MEDIPOST CO LTD (KR)
International Classes:
A61K35/44; A61K8/98; A61P17/14; A61Q7/00
Domestic Patent References:
| WO2010107287A2 | 2010-09-23 |
Foreign References:
| US20050048034A1 | 2005-03-03 | |||
| US20120251504A1 | 2012-10-04 | |||
| US20060057126A1 | 2006-03-16 | |||
| KR100771171B1 | 2007-10-29 | |||
| KR20080097593A | 2008-11-06 | |||
| KR101218101B1 | 2013-01-03 | |||
| KR101422559B1 | 2014-07-24 | |||
| KR20130009117A | 2013-01-23 | |||
| KR20140125735A | 2014-10-29 | |||
| KR100494265B1 | 2005-06-13 |
Other References:
YOO, B. Y.: "Application of mesenchymal stem cells derived from bone marrow and umbilical cord in human hair multiplication", JOURNAL OF DERMATOLOGICAL SCIENCE, 2010, pages 74 - 83, XP027437274, DOI: doi:10.1016/j.jdermsci.2010.08.017
YOO, B. Y., EVALUATION OF HUMAN UMBILICAL CORD-DERIVED MESENCHYMAL STEM CELLS ON IN VIVO HAIR INDUCING ACTIVITY, 2009, pages 179
See also references of EP 3146973A4
CELL, 1990
J. CLIN. INVEST, 2006
NATURE, 2007
BY YOO; YK SEO; JK PARK ET AL.: "Effect of Mesenchymal Cells on Human Hair Growth and Death", KOREAN J. CHEM. ENG., vol. 25, no. 2, 2008, pages 295
VA BOTCHKAREV; J KISHIMOTO: "Molecular control of epithelial-mesenchymal interactions during hair follicle cycling", J. INVEST DERMATOL. SYMP. PROC., vol. 8, no. 1, 2003, pages 46
D FISZER; M KURPISZ; T SIMINIAK: "Stem cell therapy as the reinforcement of organ regeneration", ARTIF. ORGANS, vol. 29, no. 5, 2005, pages 366
H OSHIMA; A ROCHAT; C KEDZIA ET AL.: "Y Barrandon, Morphogenesis and renewal of hair follicles from adult multipotent stem cells", CELL, vol. 104, no. 2, 2001, pages 233
KS STENN; G COTSARELIS: "Bioengineering the hair follicle: fringe benefits of stem cell technology", CURR OPIN.BIOTECHNOL., vol. 16, no. 5, 2005, pages 493
S TIEDE; JE KLOEPPER; E BODO ET AL.: "Hair follicle stem cells: Walking the maze", EUR. J. CELL BIOL., vol. 86, no. 7, 2007, pages 355
K KATAOKA; RJ MEDINA; T KAGEYAMA ET AL.: "Participation of adult mouse bone marrow cells in reconstitution of skin", AM. J. PATHOL., vol. 163, no. 4, 2003, pages 1227
C BLANPAIN; WE LOWRY; A GEOGHEGAN ET AL.: "Self-renewal, multipotency and the existence of two cell populations within an epithelial stem cell niche", CELL, vol. 118, no. 5, 2004, pages 635
MJ HOOGDUIJN; E GORJUP; PG GENEVER: "Comparative characterization of hair follicle dermal stem cells and bone marrow mesenchymal stem cells", STEM CELLS DEV., vol. 15, no. 1, 2006, pages 49
PITTINGER MF; MACKAY AM ET AL., SCIENCE, vol. 284, 1999, pages 143 - 7
LAZARUS HM; HAYNESWORTH SE ET AL., BONE MARROW TRANSPLANT, vol. 16, 1995, pages 557 - 64
JOURNAL OF INVESTIGATIVE DERMATOLOGY, vol. 124, 2005, pages 288 - 289
YOO, B. Y., EVALUATION OF HUMAN UMBILICAL CORD-DERIVED MESENCHYMAL STEM CELLS ON IN VIVO HAIR INDUCING ACTIVITY, 2009, pages 179
See also references of EP 3146973A4
CELL, 1990
J. CLIN. INVEST, 2006
NATURE, 2007
BY YOO; YK SEO; JK PARK ET AL.: "Effect of Mesenchymal Cells on Human Hair Growth and Death", KOREAN J. CHEM. ENG., vol. 25, no. 2, 2008, pages 295
VA BOTCHKAREV; J KISHIMOTO: "Molecular control of epithelial-mesenchymal interactions during hair follicle cycling", J. INVEST DERMATOL. SYMP. PROC., vol. 8, no. 1, 2003, pages 46
D FISZER; M KURPISZ; T SIMINIAK: "Stem cell therapy as the reinforcement of organ regeneration", ARTIF. ORGANS, vol. 29, no. 5, 2005, pages 366
H OSHIMA; A ROCHAT; C KEDZIA ET AL.: "Y Barrandon, Morphogenesis and renewal of hair follicles from adult multipotent stem cells", CELL, vol. 104, no. 2, 2001, pages 233
KS STENN; G COTSARELIS: "Bioengineering the hair follicle: fringe benefits of stem cell technology", CURR OPIN.BIOTECHNOL., vol. 16, no. 5, 2005, pages 493
S TIEDE; JE KLOEPPER; E BODO ET AL.: "Hair follicle stem cells: Walking the maze", EUR. J. CELL BIOL., vol. 86, no. 7, 2007, pages 355
K KATAOKA; RJ MEDINA; T KAGEYAMA ET AL.: "Participation of adult mouse bone marrow cells in reconstitution of skin", AM. J. PATHOL., vol. 163, no. 4, 2003, pages 1227
C BLANPAIN; WE LOWRY; A GEOGHEGAN ET AL.: "Self-renewal, multipotency and the existence of two cell populations within an epithelial stem cell niche", CELL, vol. 118, no. 5, 2004, pages 635
MJ HOOGDUIJN; E GORJUP; PG GENEVER: "Comparative characterization of hair follicle dermal stem cells and bone marrow mesenchymal stem cells", STEM CELLS DEV., vol. 15, no. 1, 2006, pages 49
PITTINGER MF; MACKAY AM ET AL., SCIENCE, vol. 284, 1999, pages 143 - 7
LAZARUS HM; HAYNESWORTH SE ET AL., BONE MARROW TRANSPLANT, vol. 16, 1995, pages 557 - 64
JOURNAL OF INVESTIGATIVE DERMATOLOGY, vol. 124, 2005, pages 288 - 289
Attorney, Agent or Firm:
IPS PATENT FIRM (KR)
특허법인 아이피에스 (KR)
특허법인 아이피에스 (KR)
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