Title:
HAIR GROWTH STIMULANTS AND METHOD FOR SCREENING SUBSTANCE HAVING HAIR GROWTH STIMULATING EFFECT
Document Type and Number:
WIPO Patent Application WO/2000/047172
Kind Code:
A1
Abstract:
Excellent hair growth stimulants having novel function mechanisms different from the conventional hair growth stimulants and a method for screening the same. The above-described hair growth stimulants contain as the active ingredient compounds exerting an effect of stimulating purine receptors (adenosine receptor, ATP receptor, etc.), an effect of potentiating the above effect, and an effect of liberating compounds having an effect of stimulating purine receptors (adenosine, adenosine derivatives, adenosine metabolites, etc.) from cells. The above-described screening method comprises adding a test substance to cells which have been transformed with an ABC transporter gene and a purine derivative receptor gene and using the calcium influx at this point as an indication.
Inventors:
NAKAYA YUTAKA (JP)
ARASE SEIJI (JP)
IMAMURA KOJI (JP)
ARASE SEIJI (JP)
IMAMURA KOJI (JP)
Application Number:
PCT/JP2000/000694
Publication Date:
August 17, 2000
Filing Date:
February 09, 2000
Export Citation:
Assignee:
TAISHO PHARMACEUTICAL CO LTD (JP)
NAKAYA YUTAKA (JP)
ARASE SEIJI (JP)
IMAMURA KOJI (JP)
NAKAYA YUTAKA (JP)
ARASE SEIJI (JP)
IMAMURA KOJI (JP)
International Classes:
A61K8/60; A61Q7/00; G01N33/50; G01N33/68; (IPC1-7): A61K7/06; G01N33/50; C12Q1/02
Domestic Patent References:
| WO1994009750A1 | 1994-05-11 | |||
| WO1995024885A1 | 1995-09-21 |
Foreign References:
| DE4323616A1 | 1995-01-19 | |||
| EP0540854A2 | 1993-05-12 | |||
| JPH02311411A | 1990-12-27 | |||
| JPS6442416A | 1989-02-14 | |||
| JPH10203935A | 1998-08-04 | |||
| JPH05286834A | 1993-11-02 | |||
| EP0387757A2 | 1990-09-19 | |||
| JPS63310813A | 1988-12-19 |
Other References:
LEON L. SUN ET AL.: "Cyclopentyladenosine improves cell pro-liferation, wound healing and hair growth", JOURNAL OF SURGICAL RESEARCH,, vol. 87, no. 1, November 1999 (1999-11-01), pages 14 - 24, XP002928512
CHARLES S. HARMON ET AL.: "Potassium-channel openers stimulate DNA synthesis in mouse epidermal keratinocyte and whole hair follicle cultures", SKIN PHARMACOLOGY,, vol. 6, no. 3, 1993, pages 170 - 178, XP002928513
ALLEN E. BUHL ET AL.: "Potassium channel conductance as a control mechanism in hair follicles", JOURNAL OF INVESTIGATIVE DERMATOLOGY,, vol. 101, no. 1, 1993, pages 148S - 152S, XP002928514
NOBUO IMURA ED.: "Receptor-kiso to rynsho-", ASAKURA SHOTEN,, 10 December 1993 (1993-12-10), (TOKYO), pages 464 - 474, XP002946268
SHINYA INAGAKI ET AL.: "Sulfonyl nyoso yudotai", SEIKAGAKU,, vol. 69, no. 9, 1997, pages 1067 - 1080, XP002946269
KATHERINE M. BRAY ET AL.: "A specific binding site for K+ channel openers in rat aorta", THE JOURNAL OF BIOLOGICAL CHEMISTRY,, vol. 267, no. 17, 1992, pages 11689 - 11692, XP002928515
FIONA M. GRIBBLE ET AL.: "Mechanism of cloned ATP-sensitive potassium channel activation by oleoyl-CoA", THE JOURNAL OF BIOLOGICAL CHEMISTRY,, vol. 273, no. 41, 1998, pages 26383 - 26387, XP002928516
ROBERT BRANSTROM ET AL.: "Long chain coenzyme A esters activate the pore-forming subunit (Kir6.2) of the ATP-regulated potassium channel", THE JOURNAL OF BIOLOGICAL CHEMISTRY,, vol. 273, no. 47, 1998, pages 31395 - 31400, XP002928517
CHARLES S. HARMON ET AL.: "Potassium-channel openers stimulate DNA synthesis in mouse epidermal keratinocyte and whole hair follicle cultures", SKIN PHARMACOLOGY,, vol. 6, no. 3, 1993, pages 170 - 178, XP002928513
ALLEN E. BUHL ET AL.: "Potassium channel conductance as a control mechanism in hair follicles", JOURNAL OF INVESTIGATIVE DERMATOLOGY,, vol. 101, no. 1, 1993, pages 148S - 152S, XP002928514
NOBUO IMURA ED.: "Receptor-kiso to rynsho-", ASAKURA SHOTEN,, 10 December 1993 (1993-12-10), (TOKYO), pages 464 - 474, XP002946268
SHINYA INAGAKI ET AL.: "Sulfonyl nyoso yudotai", SEIKAGAKU,, vol. 69, no. 9, 1997, pages 1067 - 1080, XP002946269
KATHERINE M. BRAY ET AL.: "A specific binding site for K+ channel openers in rat aorta", THE JOURNAL OF BIOLOGICAL CHEMISTRY,, vol. 267, no. 17, 1992, pages 11689 - 11692, XP002928515
FIONA M. GRIBBLE ET AL.: "Mechanism of cloned ATP-sensitive potassium channel activation by oleoyl-CoA", THE JOURNAL OF BIOLOGICAL CHEMISTRY,, vol. 273, no. 41, 1998, pages 26383 - 26387, XP002928516
ROBERT BRANSTROM ET AL.: "Long chain coenzyme A esters activate the pore-forming subunit (Kir6.2) of the ATP-regulated potassium channel", THE JOURNAL OF BIOLOGICAL CHEMISTRY,, vol. 273, no. 47, 1998, pages 31395 - 31400, XP002928517
Attorney, Agent or Firm:
Shiga, Masatake (Takadanobaba 3-chome Shinjuku-ku Tokyo, JP)
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