Title:
HAIRLESS TRANSGENIC ANIMAL
Document Type and Number:
WIPO Patent Application WO/2006/085673
Kind Code:
A1
Abstract:
It is intended to provide a hairless transgenic nonhuman animal to be used in developing a therapy for dermatitis such as human atopic dermatitis and drug discovery. More specifically speaking, a transgenic nonhuman animal into which a recombinant DNA containing a heparin-binding EGF gene and a type 2 keratin gene promoter capable of regulating the expression of the above-described gene has been transferred.
Inventors:
YONEKAWA HIROMICHI (JP)
TAKADA TOYOYUKI (JP)
SHITARA HIROSHI (JP)
KIKKAWA YOSHIAKI (JP)
ISHII RIE (JP)
KOHNO KENJI (JP)
TAKADA TOYOYUKI (JP)
SHITARA HIROSHI (JP)
KIKKAWA YOSHIAKI (JP)
ISHII RIE (JP)
KOHNO KENJI (JP)
Application Number:
PCT/JP2006/302590
Publication Date:
August 17, 2006
Filing Date:
February 08, 2006
Export Citation:
Assignee:
TOKYO METROPOLITAN ORG MED RES (JP)
SCIENCE AND TECHNOLOGY NAT UNI (JP)
YONEKAWA HIROMICHI (JP)
TAKADA TOYOYUKI (JP)
SHITARA HIROSHI (JP)
KIKKAWA YOSHIAKI (JP)
ISHII RIE (JP)
KOHNO KENJI (JP)
SCIENCE AND TECHNOLOGY NAT UNI (JP)
YONEKAWA HIROMICHI (JP)
TAKADA TOYOYUKI (JP)
SHITARA HIROSHI (JP)
KIKKAWA YOSHIAKI (JP)
ISHII RIE (JP)
KOHNO KENJI (JP)
International Classes:
A01K67/027; C12N15/09; G01N33/15; G01N33/50; C12N5/10
Foreign References:
| JP2004210666A | 2004-07-29 |
Other References:
PHILPOTT M.P. ET AL.: "Human hair growth in vitro", J. CELL SCI., vol. 97, no. 3, 1990, pages 463 - 471, XP003000714
HESSE M. ET AL.: "Genes for intermediate filament proteins and the draft sequence of the human genome: Novel keratin genes and a suprisingly high number of pseudogenes related to keratin genes 8 and 18", J. CELL SCI., vol. 114, no. 14, 2001, pages 2569 - 2575, XP003000713
NISHIMURA K. ET AL.: "Atopy Sei Hifuen Model Mouse (NC/Nga Mouse) ni Keiko Toyo shita Ko Allergy Yaku (Fumaric Acid Emedastine) no Hassho Yobo narabini Chiryo Koka no Kento", NITIKAWA KAISHI, vol. 114, no. 9, 2004, pages 1507 - 1516, XP003000712
MURILLAS R. ET AL.: "Expression of a dominant negative mutant of epidermal growth factor receptor in the epidermis of transgenic mice elicits striking alterations in hair follicle development and skin structure", THE EMBO JOURNAL, vol. 14, no. 21, 1995, pages 5216 - 5223, XP002377026
See also references of EP 1859676A4
HESSE M. ET AL.: "Genes for intermediate filament proteins and the draft sequence of the human genome: Novel keratin genes and a suprisingly high number of pseudogenes related to keratin genes 8 and 18", J. CELL SCI., vol. 114, no. 14, 2001, pages 2569 - 2575, XP003000713
NISHIMURA K. ET AL.: "Atopy Sei Hifuen Model Mouse (NC/Nga Mouse) ni Keiko Toyo shita Ko Allergy Yaku (Fumaric Acid Emedastine) no Hassho Yobo narabini Chiryo Koka no Kento", NITIKAWA KAISHI, vol. 114, no. 9, 2004, pages 1507 - 1516, XP003000712
MURILLAS R. ET AL.: "Expression of a dominant negative mutant of epidermal growth factor receptor in the epidermis of transgenic mice elicits striking alterations in hair follicle development and skin structure", THE EMBO JOURNAL, vol. 14, no. 21, 1995, pages 5216 - 5223, XP002377026
See also references of EP 1859676A4
Attorney, Agent or Firm:
Kobayashi, Hiroshi c/o Abe (IKUBO & KATAYAMA Fukuoka Bldg., 9th Fl.,
8-7, Yaesu 2-chom, Chuo-ku Tokyo 28, JP)
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