Title:
HANGTAIMYCIN DERIVATIVE, PREPARATION METHOD THEREFOR, AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/236797
Kind Code:
A1
Abstract:
Disclosed in the present invention are a hangtaimycin derivative, a preparation method therefor, and the use thereof. The hangtaimycin derivative is prepared by performing fermentation in an SFMR culture medium by using Streptomyces spectabilis CCTCC M2017417 or a genetically engineered strain thereof and further performing separation, purification and alcoholysis on an extract. It is found by means of screening that the hangtaimycin derivative has excellent anti-inflammatory, analgesic, anti-tumor, liver injury-preventing, cell membrane-protective and drug addiction-preventing and treating activities. The present invention thus provides a novel lead compound for development of related drugs.
Inventors:
SUN YUHUI (CN)
LI YANQIN (CN)
XIANG JIN (CN)
LUO MINGHE (CN)
DENG ZIXIN (CN)
LI YANQIN (CN)
XIANG JIN (CN)
LUO MINGHE (CN)
DENG ZIXIN (CN)
Application Number:
PCT/CN2023/096753
Publication Date:
December 14, 2023
Filing Date:
May 29, 2023
Export Citation:
Assignee:
UNIV WUHAN (CN)
International Classes:
C07K5/103; A61K38/07; A61P1/16; A61P25/36; A61P29/00; A61P35/00; C07K1/12; C07K1/20; C07K1/22; C12P21/02; C12R1/465
Foreign References:
| CN115385985A | 2022-11-25 | |||
| CN111607603A | 2020-09-01 |
Other References:
LUO MINGHE, XU HOUCHAO, DONG YULU, SHEN KUN, LU JUNLEI, YIN ZHIYONG, QI MIAOMIAO, SUN GUO, TANG LINGJIE, XIANG JIN, DENG ZIXIN, DI: "The Mechanism of Dehydrating Bimodules in trans ‐Acyltransferase Polyketide Biosynthesis: A Showcase Study on Hepatoprotective Hangtaimycin", ANGEWANDTE CHEMIE INTERNATIONAL EDITION, VERLAG CHEMIE, HOBOKEN, USA, vol. 60, no. 35, 23 August 2021 (2021-08-23), Hoboken, USA, pages 19139 - 19143, XP093114418, ISSN: 1433-7851, DOI: 10.1002/anie.202106250
LI XINGXING, FU JIE, LI YIHUA, LIU JIACHANG, GAO RONGMEI, SHI YUANYUAN, LI YIHONG, SUN HONGMIN, WANG LIFEI, LI YUHUAN, JIANG BINGY: "Cytochrome P450 Monooxygenase for Catalyzing C-42 Hydroxylation of the Glycine-Derived Fragment in Hangtaimycin Biosynthesis", ORGANIC LETTERS, AMERICAN CHEMICAL SOCIETY, US, vol. 24, no. 6, 18 February 2022 (2022-02-18), US , pages 1388 - 1393, XP093114420, ISSN: 1523-7060, DOI: 10.1021/acs.orglett.2c00242
ZUO LIJIE; JIANG BINGYA; JIANG ZHIBO; ZHAO WEI; LI SHUFEN; LIU HONGYU; HONG BIN; YU LIYAN; ZUO LIMIN; WU LINZHUAN: "Hangtaimycin, a peptide secondary metabolite discovered fromCPCC 200148 by chemical screening", THE JOURNAL OF ANTIBIOTICS, NATURE PUBLISHING GROUP UK, LONDON, vol. 69, no. 11, 1 January 1900 (1900-01-01), London, pages 835 - 838, XP037325196, ISSN: 0021-8820, DOI: 10.1038/ja.2016.29
LI XINGXING, FU JIE, LI YIHUA, LIU JIACHANG, GAO RONGMEI, SHI YUANYUAN, LI YIHONG, SUN HONGMIN, WANG LIFEI, LI YUHUAN, JIANG BINGY: "Cytochrome P450 Monooxygenase for Catalyzing C-42 Hydroxylation of the Glycine-Derived Fragment in Hangtaimycin Biosynthesis", ORGANIC LETTERS, AMERICAN CHEMICAL SOCIETY, US, vol. 24, no. 6, 18 February 2022 (2022-02-18), US , pages 1388 - 1393, XP093114420, ISSN: 1523-7060, DOI: 10.1021/acs.orglett.2c00242
ZUO LIJIE; JIANG BINGYA; JIANG ZHIBO; ZHAO WEI; LI SHUFEN; LIU HONGYU; HONG BIN; YU LIYAN; ZUO LIMIN; WU LINZHUAN: "Hangtaimycin, a peptide secondary metabolite discovered fromCPCC 200148 by chemical screening", THE JOURNAL OF ANTIBIOTICS, NATURE PUBLISHING GROUP UK, LONDON, vol. 69, no. 11, 1 January 1900 (1900-01-01), London, pages 835 - 838, XP037325196, ISSN: 0021-8820, DOI: 10.1038/ja.2016.29
Attorney, Agent or Firm:
WUHAN KEHAO INTELLECTUAL PROPERTY ATTORNEYS (SPECIAL GENERAL PARTNERSHIP) (CN)
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