Title:
HCV GENOMIC SEQUENCES FOR DIAGNOSTICS AND THERAPEUTICS
Document Type and Number:
WIPO Patent Application WO1992019743
Kind Code:
A3
Abstract:
A compsn. is claimed comprising a non-naturally occurring nucleic acid having a non-HCV-1 nucleotide sequence of 8 or more nucleotides corresponding to a nucleotide sequence within the hepatitis C virus (HCV) genome. The nucleotide sequence corresp. to a non-HCV-1 nucleotide sequence within the HCV genome may be selected from regions consisting of the NS5 region, envelope 1 region, 5' UT region and the core region.
Inventors:
CHA TAI-AN (US)
BEALL EILEEN (US)
IRVINE BRUCE (US)
KOLBERG JANICE (US)
URDEA MICHAEL S (US)
BEALL EILEEN (US)
IRVINE BRUCE (US)
KOLBERG JANICE (US)
URDEA MICHAEL S (US)
Application Number:
PCT/US1992/004036
Publication Date:
November 25, 1993
Filing Date:
May 08, 1992
Export Citation:
Assignee:
CHIRON CORP (US)
International Classes:
A61K39/29; A61K38/09; A61K38/16; A61K39/395; A61P31/12; C07K14/00; C07K14/02; C07K14/10; C07K14/18; C07K16/00; C07K16/10; C12N15/09; C12N15/40; C12N15/51; C12Q1/68; C12Q1/70; G01N33/53; G01N33/566; G01N33/576; A61K39/00; (IPC1-7): C12N15/51; C12Q1/68; C12N15/40; C12Q1/70; A61K39/29; C07K13/00; G01N33/576
Domestic Patent References:
| WO1991014779A1 | 1991-10-03 | |||
| WO1991015516A2 | 1991-10-17 |
Foreign References:
| EP0388232A1 | 1990-09-19 | |||
| GB2239245A | 1991-06-26 | |||
| EP0463848A2 | 1992-01-02 | |||
| EP0464287A1 | 1992-01-08 |
Other References:
ENOMOTO N., ET AL.: "THERE ARE TWO MAJOR TYPES OF HEPATITIS C VIRUS IN JAPAN.", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC. ORLANDO, FL, US, vol. 170., no. 03., 16 August 1990 (1990-08-16), US, pages 1021 - 1025., XP002047551, ISSN: 0006-291X, DOI: 10.1016/0006-291X(90)90494-8
OGATA N, ET AL.: "NUCLEOTIDE SEQUENCE AND MUTATION RATE OF THE H STRAIN OF HEPATITIS C VIRUS", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, NATIONAL ACADEMY OF SCIENCES, US, vol. 88, no. 08, 15 April 1991 (1991-04-15), US, pages 3392 - 3396, XP001189373, ISSN: 0027-8424, DOI: 10.1073/pnas.88.8.3392
OKAMOTO H., ET AL.: "THE 5'-TERMINAL SEQUENCE OF THE HEPATITIS C VIRUS GENOME.", JAPANESE JOURNAL OF EXPERIMENTAL MEDICINE., INSTITUTE OF MEDICAL SCIENCE, TOKYO., JP, vol. 60., no. 03., 1 January 1990 (1990-01-01), JP, pages 167 - 177., XP002042711, ISSN: 0021-5031
CHOO Q-L, ET AL.: "GENETIC ORGANIZATION AND DIVERSITY OF THE HEPATITIS C VIRUS", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, NATIONAL ACADEMY OF SCIENCES, US, vol. 88, 1 March 1991 (1991-03-01), US, pages 2451 - 2455, XP002936618, ISSN: 0027-8424, DOI: 10.1073/pnas.88.6.2451
WEINER A J, ET AL.: "VARIABLE AND HYPERVARIABLE DOMAINS ARE FOUND IN THE REGIONS OF HCV CORRESPONDING TO THE FLAVIVIRUS ENVELOPE AND NS1 PROTEINS AND THE PESTVIRUS ENVELOPE GLYCOPROTEINS", VIROLOGY, ELSEVIER, AMSTERDAM, NL, vol. 180, no. 02, 1 January 1991 (1991-01-01), AMSTERDAM, NL, pages 842 - 848, XP008029804, ISSN: 0042-6822, DOI: 10.1016/0042-6822(91)90104-J
OGATA N, ET AL.: "NUCLEOTIDE SEQUENCE AND MUTATION RATE OF THE H STRAIN OF HEPATITIS C VIRUS", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, NATIONAL ACADEMY OF SCIENCES, US, vol. 88, no. 08, 15 April 1991 (1991-04-15), US, pages 3392 - 3396, XP001189373, ISSN: 0027-8424, DOI: 10.1073/pnas.88.8.3392
OKAMOTO H., ET AL.: "THE 5'-TERMINAL SEQUENCE OF THE HEPATITIS C VIRUS GENOME.", JAPANESE JOURNAL OF EXPERIMENTAL MEDICINE., INSTITUTE OF MEDICAL SCIENCE, TOKYO., JP, vol. 60., no. 03., 1 January 1990 (1990-01-01), JP, pages 167 - 177., XP002042711, ISSN: 0021-5031
CHOO Q-L, ET AL.: "GENETIC ORGANIZATION AND DIVERSITY OF THE HEPATITIS C VIRUS", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, NATIONAL ACADEMY OF SCIENCES, US, vol. 88, 1 March 1991 (1991-03-01), US, pages 2451 - 2455, XP002936618, ISSN: 0027-8424, DOI: 10.1073/pnas.88.6.2451
WEINER A J, ET AL.: "VARIABLE AND HYPERVARIABLE DOMAINS ARE FOUND IN THE REGIONS OF HCV CORRESPONDING TO THE FLAVIVIRUS ENVELOPE AND NS1 PROTEINS AND THE PESTVIRUS ENVELOPE GLYCOPROTEINS", VIROLOGY, ELSEVIER, AMSTERDAM, NL, vol. 180, no. 02, 1 January 1991 (1991-01-01), AMSTERDAM, NL, pages 842 - 848, XP008029804, ISSN: 0042-6822, DOI: 10.1016/0042-6822(91)90104-J
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