Title:
HCV NS-3 SERINE PROTEASE INHIBITORS
Document Type and Number:
WIPO Patent Application WO2005073216
Kind Code:
A3
Abstract:
Compounds of the formula (F) where the variables are as defined in the specification inhibit the NS3 protease of flavivirus sych as hepatitis C virus (HCV). The compounds comprise a novel linkage between a heterocyclic P2 unit and those portions of the inhibitor more distal to the nominal cleavage site of the native substrate, which linkage reverses the orientation of peptidic bonds on the distal side relative to those proximal to the cleavage site.
Inventors:
ROSENQUIST AASA (SE)
THORSTENSSON FREDRIK (SE)
JOHANSSON PER-OLA (SE)
KVARNSTROEM INGEMAR (SE)
AYESA SUSANA (SE)
CLASSON BJOERN (SE)
RAKOS LAZLO (SE)
SAMUELSSON BERTIL (SE)
THORSTENSSON FREDRIK (SE)
JOHANSSON PER-OLA (SE)
KVARNSTROEM INGEMAR (SE)
AYESA SUSANA (SE)
CLASSON BJOERN (SE)
RAKOS LAZLO (SE)
SAMUELSSON BERTIL (SE)
Application Number:
PCT/SE2005/000096
Publication Date:
October 06, 2005
Filing Date:
January 28, 2005
Export Citation:
Assignee:
MEDIVIR AB (SE)
ROSENQUIST AASA (SE)
THORSTENSSON FREDRIK (SE)
JOHANSSON PER-OLA (SE)
KVARNSTROEM INGEMAR (SE)
AYESA SUSANA (SE)
CLASSON BJOERN (SE)
RAKOS LAZLO (SE)
SAMUELSSON BERTIL (SE)
ROSENQUIST AASA (SE)
THORSTENSSON FREDRIK (SE)
JOHANSSON PER-OLA (SE)
KVARNSTROEM INGEMAR (SE)
AYESA SUSANA (SE)
CLASSON BJOERN (SE)
RAKOS LAZLO (SE)
SAMUELSSON BERTIL (SE)
International Classes:
C07C235/40; C07C237/04; C07C237/10; C07C247/04; C07C271/22; C07C281/02; C07C309/73; C07C311/51; C07D207/16; C07D215/233; C07D245/04; C07D401/12; C07D405/14; C07D409/14; C07D413/14; C07D417/04; C07D417/14; C07D487/04; C07K5/02; C07K5/06; C07D215/22; C07D; (IPC1-7): C07K5/02; C07D401/12; C07D409/14; C07D405/14; C07D413/14; C07D417/14; C07D207/16; A61K31/47; A61P31/12; C07D487/04
Domestic Patent References:
| WO2000009543A2 | 2000-02-24 | |||
| WO2005010029A1 | 2005-02-03 |
Foreign References:
| US20030186895A1 | 2003-10-02 | |||
| EP0443132A1 | 1991-08-28 | |||
| EP0126587A1 | 1984-11-28 |
Other References:
ZANOTTI, GIANCARLO ET AL: "Synthesis of analogs of amaninamide, an amatoxin from the white Amanita virosa mushroom", INTERNATIONAL JOURNAL OF PEPTIDE & PROTEIN RESEARCH , 30(4), 450-9 CODEN: IJPPC3; ISSN: 0367-8377, 1987, XP008050698
ZANOTTI, GIANCARLO ET AL: "Analogs of amanin. Synthesis of Ile3-amaninamide and its diastereoisomeric (S)-sulfoxide", INTERNATIONAL JOURNAL OF PEPTIDE & PROTEIN RESEARCH , 18(2), 162-8 CODEN: IJPPC3; ISSN: 0367-8377, 1981, XP008050700
ZANOTTI, GIANCARLO ET AL: "Analogs of amanin. Synthesis of Ile3-amaninamide and its diastereoisomeric (S)-sulfoxide", INTERNATIONAL JOURNAL OF PEPTIDE & PROTEIN RESEARCH , 18(2), 162-8 CODEN: IJPPC3; ISSN: 0367-8377, 1981, XP008050700
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