Title:
HEART FAILURE TREATMENT VIA CARDIOTONIC EFFECT BY TRPC3/6/7 CHANNEL ACTIVATION
Document Type and Number:
WIPO Patent Application WO/2024/043242
Kind Code:
A1
Abstract:
Provided is a drug for preventing or treating heart failure, that is effective and that does not have a blood pressure lowering effect. The present invention pertains to: a pharmaceutical composition for preventing or treating heart failure or skeletal muscle failure, the pharmaceutical composition containing a TRPC3/6/7 channel activator; and a related screening method.
Inventors:
NISHIDA MOTOHIRO (JP)
NISHIYAMA KAZUHIRO (JP)
KATO YURI (JP)
NISHIMURA AKIYUKI (JP)
NAGATA RYU (JP)
MORI YASUO (JP)
NAKAGAWA YASUAKI (JP)
KUWAHARA KOICHIRO (JP)
NISHIYAMA KAZUHIRO (JP)
KATO YURI (JP)
NISHIMURA AKIYUKI (JP)
NAGATA RYU (JP)
MORI YASUO (JP)
NAKAGAWA YASUAKI (JP)
KUWAHARA KOICHIRO (JP)
Application Number:
PCT/JP2023/030211
Publication Date:
February 29, 2024
Filing Date:
August 22, 2023
Export Citation:
Assignee:
UNIV KYUSHU NAT UNIV CORP (JP)
INTER UNIV RESEARCH INSTITUTE CORPORATION NATIONAL INSTITUTES OF NATURAL SCIENCES (JP)
UNIV OSAKA (JP)
UNIV KYOTO (JP)
UNIV SHINSHU (JP)
INTER UNIV RESEARCH INSTITUTE CORPORATION NATIONAL INSTITUTES OF NATURAL SCIENCES (JP)
UNIV OSAKA (JP)
UNIV KYOTO (JP)
UNIV SHINSHU (JP)
International Classes:
A61K45/00; A61K31/05; A61K31/454; A61K31/495; A61K31/496; A61P9/04; A61P21/00; C07D401/00; G01N33/15; G01N33/50
Domestic Patent References:
| WO2022118966A1 | 2022-06-09 | |||
| WO2021165992A1 | 2021-08-26 |
Foreign References:
| JP2002520260A | 2002-07-09 | |||
| JP2018502823A | 2018-02-01 |
Other References:
大久保礼真 他, TRPC6チャネルを介したZn2+流入による心臓の圧受容反射応答制御, フォーラム２０２２：衛生薬学・環境トキシコロジー 講演要旨集, 17 August 2022, p. 158, non-official translation (OKUBO, Reishin et al., Cardiac Baroreceptor Response Control by Zn2+ Inflow via TRPC6 Channel, Forum 2022: Health Pharmacy, Environmental Toxicology, Lecture Abstracts)
ODA SAYAKA, NISHIYAMA KAZUHIRO, FURUMOTO YUKA, YAMAGUCHI YOHEI, NISHIMURA AKIYUKI, TANG XIAOKANG, KATO YURI, NUMAGA-TOMITA TAKURO,: "Myocardial TRPC6-mediated Zn2+ influx induces beneficial positive inotropy through β-adrenoceptors", NATURE COMMUNICATIONS, NATURE PUBLISHING GROUP, UK, vol. 13, no. 1, 26 October 2022 (2022-10-26), UK, XP093143545, ISSN: 2041-1723, DOI: 10.1038/s41467-022-34194-9
ODA SAYAKA, NISHIYAMA KAZUHIRO, FURUMOTO YUKA, YAMAGUCHI YOHEI, NISHIMURA AKIYUKI, TANG XIAOKANG, KATO YURI, NUMAGA-TOMITA TAKURO,: "Myocardial TRPC6-mediated Zn2+ influx induces beneficial positive inotropy through β-adrenoceptors", NATURE COMMUNICATIONS, NATURE PUBLISHING GROUP, UK, vol. 13, no. 1, 26 October 2022 (2022-10-26), UK, XP093143545, ISSN: 2041-1723, DOI: 10.1038/s41467-022-34194-9
Attorney, Agent or Firm:
YAMAO, Norihito et al. (JP)
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