Title:
HEART-PROTECTING FACTOR MIR-139-3P AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2024/021024
Kind Code:
A1
Abstract:
A heart-protecting factor miR-139-3p and use thereof. Provided is use of miR-139-3p in the preparation of a formulation for regulating and controlling macrophage polarization. Also provided are use of a reagent material that overexpresses miR-139-3p in exosomes in the preparation of a formulation for promoting the polarization of macrophages to type M2, use of a reagent material that inhibits and/or knocks down miR-139-3p expression in exosomes in the preparation of a formulation for inhibiting the polarization of macrophages to type M2, and use of miR-139-3p in the preparation of a formulation for regulating and controlling signal transduction and the expression of transcription activator 1. Exosomes that overexpress miR-139-3p can deliver heart-protecting miR-139-3p into macrophages, and miR-139-3p inhibits Stat1 expression and activation to promote M2 macrophage polarization.
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Inventors:
YANG YUEJIN (CN)
NING YU (CN)
GONG ZHAOTING (CN)
XU JUNYAN (CN)
NING YU (CN)
GONG ZHAOTING (CN)
XU JUNYAN (CN)
Application Number:
PCT/CN2022/108991
Publication Date:
February 01, 2024
Filing Date:
July 29, 2022
Export Citation:
Assignee:
FUWAI HOSPITAL CHINESE ACAD OF MEDICAL SCIENCES AND PEKING UNION MEDICAL COLLEGE (CN)
International Classes:
A61K31/713; A61P9/10
Foreign References:
| CN108048551A | 2018-05-18 | |||
| CN110484615A | 2019-11-22 |
Other References:
HE CHU-QI, HAO ZHONG; DING-XIN LONG: "Target gene prediction and bioinformatic analysis of hsa-miR-139-3p", CHINA JOURNAL OF MODERN MEDICINE, ZHONGNAN DAXUE, CN, vol. 29, no. 17, 12 September 2019 (2019-09-12), CN , pages 22 - 28, XP093134023, ISSN: 1005-8982, DOI: 10.3969/j.issn.1005-8982.2019.17.005
HUI YU, YANG XIAO-MIN; QU SHUANG-LI; QIN LEI; FENG YUE: "Expression and effect of miR-139-3p in apoptotic neonatal rat cardiomyocytes induced by hypoxia", CHINESE JOURNAL OF PATHOPHYSIOLOGY, ZHONGGUO BINGLI SHENGLI XUEHUI, BEIJING, CN, vol. 35, no. 4, 23 April 2019 (2019-04-23), CN , pages 667 - 672, XP093134024, ISSN: 1000-4718, DOI: 10.3969/j.issn.1000-4718.2019.04.014
MIN ZHONG, ZHANG YINGYING; LÜ KUN: "Preliminary study on the role of miR-139 in regulating macrophage polarization in allergic asthma ", ACTA ACADEMIAE MEDICINAE WANNAN, WANNAN MEDICAL COLLEGE, CN, vol. 40, no. 5, 15 October 2021 (2021-10-15), CN , pages 409 - 412, XP093134027, ISSN: 1002-0217, DOI: 10.3969/j.issn.1002-0217.2021.05.001
CAO PEI, MA BO, SUN DING, ZHANG WEIGANG, QIU JUNYI, QIN LEI, XUE XIAOFENG: "hsa_circ_0003410 promotes hepatocellular carcinoma progression by increasing the ratio of M2/M1 macrophages through the miR‐139‐3p/CCL5 axis", CANCER SCIENCE, JAPANESE CANCER ASSOCIATION, TOKYO, JP, vol. 113, no. 2, 1 February 2022 (2022-02-01), JP , pages 634 - 647, XP093134028, ISSN: 1347-9032, DOI: 10.1111/cas.15238
HUI YU, YANG XIAO-MIN; QU SHUANG-LI; QIN LEI; FENG YUE: "Expression and effect of miR-139-3p in apoptotic neonatal rat cardiomyocytes induced by hypoxia", CHINESE JOURNAL OF PATHOPHYSIOLOGY, ZHONGGUO BINGLI SHENGLI XUEHUI, BEIJING, CN, vol. 35, no. 4, 23 April 2019 (2019-04-23), CN , pages 667 - 672, XP093134024, ISSN: 1000-4718, DOI: 10.3969/j.issn.1000-4718.2019.04.014
MIN ZHONG, ZHANG YINGYING; LÜ KUN: "Preliminary study on the role of miR-139 in regulating macrophage polarization in allergic asthma ", ACTA ACADEMIAE MEDICINAE WANNAN, WANNAN MEDICAL COLLEGE, CN, vol. 40, no. 5, 15 October 2021 (2021-10-15), CN , pages 409 - 412, XP093134027, ISSN: 1002-0217, DOI: 10.3969/j.issn.1002-0217.2021.05.001
CAO PEI, MA BO, SUN DING, ZHANG WEIGANG, QIU JUNYI, QIN LEI, XUE XIAOFENG: "hsa_circ_0003410 promotes hepatocellular carcinoma progression by increasing the ratio of M2/M1 macrophages through the miR‐139‐3p/CCL5 axis", CANCER SCIENCE, JAPANESE CANCER ASSOCIATION, TOKYO, JP, vol. 113, no. 2, 1 February 2022 (2022-02-01), JP , pages 634 - 647, XP093134028, ISSN: 1347-9032, DOI: 10.1111/cas.15238
Attorney, Agent or Firm:
BEIJING SANYOU INTELLECTUAL PROPERTY AGENCY LTD. (CN)
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