Title:
HEAVY-CHAIN ANTIBODY IN WHICH O-LINKED SUGAR CHAIN MODIFICATION IS SUPPRESSED
Document Type and Number:
WIPO Patent Application WO/2021/039574
Kind Code:
A1
Abstract:
The present invention provides, in order to obtain a uniform quality for heavy-chain antibodies, a heavy-chain antibody that is less susceptible to modification by O-linked sugar chains. The heavy-chain antibody according to the present invention is characterized by including a heavy chain variable domain having a structure of (FR1)-(VH-CDR1)-(FR2)-(VH-CDR2)-(FR3)-(VH-CDR3)-(FR4), wherein, in the amino acid sequence of FR3, at least one serine or threonine residue is substituted with an amino acid other than serine or threonine. The present invention also pertains to: a nucleic acid having a base sequence encoding the amino acid sequence of the heavy-chain antibody; and a vector and a host cell including said nucleic acid.
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Inventors:
ARATAKE MASAHIRO (JP)
Application Number:
PCT/JP2020/031425
Publication Date:
March 04, 2021
Filing Date:
August 20, 2020
Export Citation:
Assignee:
KANEKA CORP (JP)
International Classes:
A61K39/395; A61K48/00; C07K16/00; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/13
Domestic Patent References:
| WO2008099968A1 | 2008-08-21 | |||
| WO2005085433A1 | 2005-09-15 |
Foreign References:
| JP2008539775A | 2008-11-20 | |||
| JP2008539772A | 2008-11-20 | |||
| JP2002000276A | 2002-01-08 |
Attorney, Agent or Firm:
HIRAKI & ASSOCIATES (JP)
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