Title:
HEMIASTERLIN DERIVATIVE AND ANTIBODY-DRUG CONJUGATE THEREOF
Document Type and Number:
WIPO Patent Application WO/2020/166592
Kind Code:
A1
Abstract:
A compound or represented by formula (1) or a salt thereof (in the formula, R1 represents a hydrogen atom or a sulfonyl group, and Z represents a group represented by formula (Z-1), etc.).
Inventors:
BAN HITOSHI (JP)
SUWA ATSUSHI (JP)
SUWA ATSUSHI (JP)
Application Number:
PCT/JP2020/005291
Publication Date:
August 20, 2020
Filing Date:
February 12, 2020
Export Citation:
Assignee:
SUMITOMO DAINIPPON PHARMA CO LTD (JP)
International Classes:
A61K39/395; A61K38/21; A61K45/00; A61K47/68; A61P3/00; A61P5/00; A61P35/00; A61P35/02; A61P37/02; A61P43/00; C07K5/027; C07K5/065; C07K16/00; C07K16/28
Domestic Patent References:
| WO2014057436A2 | 2014-04-17 | |||
| WO2019031614A1 | 2019-02-14 |
Foreign References:
| JP2016516063A | 2016-06-02 | |||
| JP2007537136A | 2007-12-20 | |||
| JP2012522513A | 2012-09-27 | |||
| JP2011500725A | 2011-01-06 | |||
| JP2017508741A | 2017-03-30 |
Other References:
ZASK, A. ET AL.: "Synthesis and Biological Activity of Analogues of the Antimicrotubule Agent N, beta, beta-Trimethyl -L-phenylalanyl-N1-[(1S, 2E)-3- carboxy-1-isopropylbut-2-enyl]-N1, 3-dimethyl-L- valinamide (HTI-286", JOURNAL OF MEDICINAL CHEMISTRY, vol. 47, no. 19, 2004, pages 4774 - 4786; 4780, XP002310106
Attorney, Agent or Firm:
HASEGAWA Yoshiki et al. (JP)
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