Title:
HEMOGLOBIN DERIVATIVE CO-CONJUGATED WITH FATTY ACID-LINKED PEG AND ALKOXY PEG AS A BLOOD SUBSTITUTE
Document Type and Number:
WIPO Patent Application WO/2021/261712
Kind Code:
A1
Abstract:
The invention relates to hemoglobin derivative, particularly hemoglobin which is co-conjugated with both fatty acid-linked polyethylene glycol (FA-PEG) derivatives and alkoxy polyethylene glycol (alkoxy-PEG) derivatives, and a method for making such hemoglobin derivative. Various embodiments of the invention include crosslinked hemoglobin which is co-conjugated with both FA-PEG derivatives and alkoxy-PEG derivatives. Such hemoglobin derivative according to the invention exhibit non-toxicity and extended intravascular retention time.
Inventors:
NHO KWANG (KR)
AHN MINJUNG (KR)
HYUN CHANGMIN (KR)
LEE JUNGHOON (KR)
AHN MINJUNG (KR)
HYUN CHANGMIN (KR)
LEE JUNGHOON (KR)
Application Number:
PCT/KR2021/003530
Publication Date:
December 30, 2021
Filing Date:
March 22, 2021
Export Citation:
Assignee:
SUNBIO INC (KR)
International Classes:
A61K47/60; A61K38/42; A61K47/54; A61P3/10; A61P7/00; A61P9/10; A61P25/00; A61P27/02; A61P35/00
Domestic Patent References:
| WO2004081053A1 | 2004-09-23 |
Foreign References:
| US20040072729A1 | 2004-04-15 | |||
| KR20000061432A | 2000-10-16 | |||
| US20100075379A1 | 2010-03-25 | |||
| EP1465643B1 | 2008-01-02 |
Attorney, Agent or Firm:
DANA PATENT LAW FIRM (KR)
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