Title:
HEPARIN PENTASACCHARIDE-BASED LOW MOLECULAR WEIGHT HEPARIN MIMETIC, PREPARATION METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2024/061270
Kind Code:
A1
Abstract:
Disclosed in the present invention is a heparin pentasaccharide-based low molecular weight heparin mimetic, which is a heparin pentasaccharide dimer or heparin pentasaccharide trimer. Also disclosed in the present invention is a preparation method for a heparin pentasaccharide dimer or heparin pentasaccharide trimer. The heparin pentasaccharide dimer or heparin pentasaccharide trimer of the present invention has anticoagulant activity, and the heparin pentasaccharide trimer can be neutralized by protamine.
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Inventors:
LI TIEHAI (CN)
ZHANG LIANGWEI (CN)
MA WENJING (CN)
ZHANG LIANGWEI (CN)
MA WENJING (CN)
Application Number:
PCT/CN2023/120054
Publication Date:
March 28, 2024
Filing Date:
September 20, 2023
Export Citation:
Assignee:
SHANGHAI INST MATERIA MEDICA CAS (CN)
International Classes:
C08B37/10
Foreign References:
| CN114957354A | 2022-08-30 | |||
| CN113583151A | 2021-11-02 | |||
| CN113666980A | 2021-11-19 | |||
| US5753445A | 1998-05-19 |
Attorney, Agent or Firm:
XU & PARTNERS, LLC. (CN)
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