Title:
HEPATITIS B VIRUS RECEPTOR OATP AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2024/012423
Kind Code:
A1
Abstract:
Provided in the present invention are a hepatitis B virus receptor OATP and the use thereof. Specifically, provided in the present invention is the use of a substance in the preparation of an agent for preventing and/or treating hepatitis B virus (HBV) and/or hepatitis D virus (HDV) infections in an animal or diseases related to said infections, wherein the substance prevents or reduces the interaction between HBV and/or HDV and an organic anion transporting polypeptide (OATP) in the animal, and/or prevents or reduces the expression and/or function of OATP in the animal. Further provided in the present invention are a cell model and an animal model having susceptibility to HBV and/or HDV that are obtained by means of transferring an exogenous SLCO gene into a cell or expressing an exogenous OATP protein, and a method for establishing the models; a method for delivering a drug by means of targeting OATP, and a drug delivery carrier targeting OATP; and an OATP-targeted delivery polypeptide carrier derived from a hepadnaviridae surface antigen.
Inventors:
LIU HONGLI (CN)
Application Number:
PCT/CN2023/106678
Publication Date:
January 18, 2024
Filing Date:
July 11, 2023
Export Citation:
Assignee:
SHANGHAI HEP PHARMACEUTICAL CO LTD (CN)
International Classes:
A61K38/16; A61P1/16; A61P31/20; C07K14/705
Foreign References:
| CN109718364A | 2019-05-07 | |||
| CN104130316A | 2014-11-05 | |||
| CN108064238A | 2018-05-22 | |||
| CN111542340A | 2020-08-14 | |||
| CN114174332A | 2022-03-11 |
Attorney, Agent or Firm:
SHANGHAI PATENT & TRADEMARK LAW OFFICE, LLC (CN)
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