HEPATITIS C VIRUS POLYMERASE INHIBITORS WITH HETEROBICYCLIC STRUCTURE

WIPO Patent Application WO2003010140

A3

An isomer, enantiomer, diastereoisomer, or tautomer of a compound, represented by formula (I) wherein: A is O, S, NR1, or CR1, wherein R1 is defined herein; represents either a single or a double bond;R2 is selected from: H, halogen, R21, OR21, SR21, COOR21, SO2N(R22)2, N(R22)2, CON(R22)2, NR22C(O)R22 or NR22C(O)NR22 wherein R21 and each R22 is defined herein;B is NR3 or CR3, with the proviso that one of A or B is either CR1 or CR3, wherein R3 is defined herein;K is N or CR4, wherein R4 is defined herein;L is N or CR5, wherein R5 has the same definition as R4 defined above;M is N or CR7, wherein R7 has the same definition as R4 defined above;Y1 is O or S;Z is N(R6a)R6 or OR6, wherein R6a is H or alkyl or NR61R62 wherein R61 and R62 are defined herein;a salt or a derivative thereof, as an inhibitor of HCV NS5B polymerase.

JP3274223	LOW-IRRITANT D-PHENOTHRIN SHAMPOO
JP5019882	Hydroxylamine derivative
WO/1992/011867	NOVEL GLUCOHYDROLASE INHIBITORS USEFUL AS ANTIDIABETIC AGENTS

BEAULIEU PIERRE LOUIS (CA)
FAZAL GULREZ (CA)
KUKOLJ GEORGE (CA)
JOLICOEUR ERIC (CA)
GILLARD JAMES (CA)
POUPART MARC-ANDRE (CA)
RANCOURT JEAN (CA)

PCT/CA2002/001127

July 10, 2003

July 18, 2002

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BOEHRINGER INGELHEIM CA LTD (CA)
BEAULIEU PIERRE LOUIS (CA)
FAZAL GULREZ (CA)
KUKOLJ GEORGE (CA)
JOLICOEUR ERIC (CA)
GILLARD JAMES (CA)
POUPART MARC-ANDRE (CA)
RANCOURT JEAN (CA)

A61K31/13; A61K31/381; A61K31/404; A61K31/405; A61K31/4184; A61K31/422; A61K31/427; A61K31/428; A61K31/437; A61K31/443; A61K31/4436; A61K31/4439; A61K31/454; A61K31/4545; A61K31/4709; A61K31/497; A61K31/506; A61K31/53; A61K31/5377; A61K31/7052; A61K38/21; A61K45/00; A61P31/12; A61P31/14; A61P37/02; A61P43/00; C07D209/08; C07D209/14; C07D209/20; C07D209/30; C07D209/42; C07D333/62; C07D401/04; C07D401/06; C07D401/12; C07D401/14; C07D403/04; C07D405/04; C07D405/12; C07D405/14; C07D407/14; C07D409/04; C07D409/14; C07D413/04; C07D413/14; C07D417/04; C07D417/12; C07D417/14; C07D471/02; C07D471/04; C07D491/02; C07D498/02; C07H19/056; C07D; (IPC1-7): A61K31/404; A61K31/381; A61K31/4402; A61K31/437; C07D209/08; C07D405/04; C07D409/04; C07D401/04; C07D403/04; C07D417/04; C07D413/04; C07D471/04

WO2001047883A1	2001-07-05
WO1997048697A1	1997-12-24
WO2001032653A1	2001-05-10
WO2001030774A1	2001-05-03
WO1999028297A1	1999-06-10
WO2001047922A2	2001-07-05
WO2002004425A2	2002-01-17

US5059621A	1991-10-22
US6069156A	2000-05-30
JPH1067682A	1998-03-10
JPH10114654A	1998-05-06
JPH09124632A	1997-05-13
US3565912A	1971-02-23
JP2001122855A	2001-05-08
US5912260A	1999-06-15
US4740519A	1988-04-26
EP0987250A1	2000-03-22
EP0242167A2	1987-10-21
US20020065418A1	2002-05-30
US6358992B1	2002-03-19

DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; HISHMAT, O. H. ET AL: "Synthesis of pharmacologically active indoles", XP002233311, retrieved from STN Database accession no. 132:49850
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; FUERSTNER, ALOIS ET AL: "Titanium-induced zipper reactions", XP002233857, retrieved from STN Database accession no. 123:83146
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; ROTH, H. J. ET AL: "Synthesis of indole and carbazole derivatives by condensation of.alpha.-hydroxyketones and aromatic amines", XP002233858, retrieved from STN Database accession no. 77:19476
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; YOUNGDALE, GILBERT A. ET AL: "Synthesis and antiinflammatory activity of 5-substituted 2,3-bis(p-methoxyphenyl)indoles", XP002233859, retrieved from STN Database accession no. 71:91199

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