HEPATOMA CELL-TARGETING ANTIMICROBIAL PEPTIDE CHIMERA M27-39-HTPP AND USE THEROF

WIPO Patent Application WO/2019/169697

A1

Disclosed is a hepatoma cell-targeting antimicrobial peptide chimera M27-39-HTPP and the use thereof, wherein same is obtained by the fusion of positions 27 to 39 of Musca domestica cecropin with a hepatocyte-targeting and penetrating peptide (HTPP), the amino acid sequence of which is as shown in SEQ ID NO: 1. The present invention uses a solid phase chemical synthesis method to obtain the crude M27-39-HTPP targeting antimicrobial peptide chimera, and uses reverse-phase high performance liquid chromatography and electrospray mass spectrometry to purify and identify the synthesized polypeptide. The hepatocyte-targeting M27-39-HTPP has a targeted anti-liver cancer effect, and has great practical significance and broad application prospects in the fields of medicine and bio-pharmacy, especially in the field of the preparation of anti-hepatoma drugs.

LU XUEMEI (CN)
CHEN ZHAOXIA (CN)
GUI SHUIQING (CN)
JIN XIAOBAO (CN)
ZHU JIAYONG (CN)

PCT/CN2018/083403

September 12, 2019

April 17, 2018

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UNIV GUANGDONG PHARM (CN)

C07K14/435; A61K38/17; A61P35/00

LU, XUEMEI ET AL.: "Construction of HTPP-MDC's Prokaryotic Expression Vector and Its Expression in Escherichia Coli", CHEMISTRY & BIOENGINEERING, vol. 29, no. 5, 31 December 2012 (2012-12-31), pages 16 - 18; 45
LU, XUEMEI ET AL.: "Construction and Molecular Characteristics of Fusion Gene HTPP-MDC", GENOMICS AND APPLIED BIOLOGY, vol. 31, no. 3, 31 December 2012 (2012-12-31), pages 226 - 230

YOGO PATENT AND TRADEMARK AGENCY LIMITED COMPANY (CN)

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