Title:
HER2 AFFIBODY, DIAGNOSTIC OR THERAPEUTIC NUCLIDE-LABELED SUBSTANCE, AND PREPARATION METHOD FOR NUCLIDE-LABELED SUBSTANCE AND APPLICATION OF NUCLIDE-LABELED SUBSTANCE
Document Type and Number:
WIPO Patent Application WO/2021/238842
Kind Code:
A1
Abstract:
The present invention relates to the technical field of clinical nuclear medicine, and relates to an HER2 affibody, a diagnostic or therapeutic nuclide-labeled substance, and a preparation method for the nuclide-labeled substance and an application of the nuclide-labeled substance. The sequence of the HER2 affibody is as shown in SEQ ID NO: 1. The sequence of the HER2 affibody designed and synthesized in the present invention has good in vivo stability and pharmacokinetic properties; both the HER2 affibody and a molecular probe labeled and synthesized with a diagnostic or therapeutic radionuclide have good affinity and functional activity for HER2 molecules; and the HER2 affibody is expected to become a radiopharmaceutical for targeted HER2 imaging and tumor treatment having good application prospects.
Inventors:
YANG ZHI (CN)
GUO XIAOYI (CN)
ZHU HUA (CN)
ZHOU NINA (CN)
LIU TELI (CN)
GUO XIAOYI (CN)
ZHU HUA (CN)
ZHOU NINA (CN)
LIU TELI (CN)
Application Number:
PCT/CN2021/095455
Publication Date:
December 02, 2021
Filing Date:
May 24, 2021
Export Citation:
Assignee:
BEIJING INSTITUTE FOR CANCER RES (CN)
International Classes:
C07K14/00; A61K51/08; A61P35/00; A61K101/02; A61K103/00
Domestic Patent References:
| WO2016151478A1 | 2016-09-29 |
Foreign References:
| CN111592584A | 2020-08-28 | |||
| CN108434469A | 2018-08-24 | |||
| CN101287503A | 2008-10-15 |
Other References:
XU YUPING, BAI ZHICHENG, HUANG QIANHUAN, PAN YUNYUN, PAN DONGHUI, WANG LIZHEN, YAN JUNJIE, WANG XINYU, YANG RUNLIN, YANG MIN: "PET of HER2 Expression with a Novel 18 FAl Labeled Affibody", JOURNAL OF CANCER, vol. 8, no. 7, 1 January 2017 (2017-01-01), AU , pages 1170 - 1178, XP055873160, ISSN: 1837-9664, DOI: 10.7150/jca.18070
Attorney, Agent or Firm:
CHENGDU CENTRAL ASIA PATENT AGENCY CO., LTD (CN)
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