Title:
HETEROAROMATIC RING-CONTAINING ALKYNYL COMPOUND, AND PREPARATION METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/169453
Kind Code:
A1
Abstract:
The present invention relates to a heteroaromatic ring-containing alkynyl compound, and a preparation method therefor and the use thereof. The heteroaromatic ring-containing alkynyl compound is a compound represented by a formula (I), or a deuterated compound, a pharmaceutically acceptable salt, a solvate, an ester, an acid, a metabolite or a prodrug thereof. The compound as represented by formula (I) of the present invention has a strong killing effect on tumor cells carrying primary KIT mutation and drug-resistant KIT mutation.
Inventors:
HU YOUHONG (CN)
LOU LIGUANG (CN)
XIE ZHICHENG (CN)
LI LIN (CN)
WANG LEI (CN)
LOU LIGUANG (CN)
XIE ZHICHENG (CN)
LI LIN (CN)
WANG LEI (CN)
Application Number:
PCT/CN2023/080231
Publication Date:
September 14, 2023
Filing Date:
March 08, 2023
Export Citation:
Assignee:
SHANGHAI INST MATERIA MEDICA CAS (CN)
International Classes:
C07D401/04; A61K31/437; A61K31/4439; A61K31/444; A61K31/4545; A61K31/4725; A61K31/5025; A61K31/506; A61K31/519; A61P25/00; A61P29/00; A61P35/00; A61P37/02; C07D401/14; C07D409/12; C07D409/14; C07D417/14; C07D487/04
Foreign References:
| CN109843294A | 2019-06-04 | |||
| CN105431436A | 2016-03-23 | |||
| CN104211639A | 2014-12-17 | |||
| CN111662227A | 2020-09-15 | |||
| CN106146391A | 2016-11-23 | |||
| CN108456163A | 2018-08-28 |
Other References:
ELIZABETH A. LAROCQUE; N. NAGANNA; CLEMENT OPOKU‐TEMENG; ALYSSA M. LAMBRECHT; HERMAN O. SINTIM: "Alkynylnicotinamide‐Based Compounds as ABL1 Inhibitors with Potent Activities against Drug‐Resistant CML Harboring ABL1(T315I) Mutant Kinase", CHEMMEDCHEM COMMUNICATIONS, WILEY-VCH, DE, vol. 13, no. 12, 22 May 2018 (2018-05-22), DE , pages 1172 - 1180, XP072421730, ISSN: 1860-7179, DOI: 10.1002/cmdc.201700829
Attorney, Agent or Firm:
KINGSOUND & PARTNERS (CN)
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