Title:
HETEROARYL COMPOUNDS AS EGFR INHIBITORS AND THEIR USES
Document Type and Number:
WIPO Patent Application WO/2024/026056
Kind Code:
A3
Abstract:
Disclosed are heteroaryl compounds and pharmaceutical compositions thereof, which are useful for inhibiting EGFR, as well as methods for using such compounds to treat cancer associated with an EGFR or HER2 exon 20 insertion mutation.
Inventors:
FAN JIE (US)
QIAN YIMIN (US)
HE WEI (US)
LIU KE (US)
HUANG PIN (US)
SUN XIANGYAN (US)
SU JIE (US)
LIU JI (US)
QIAN YIMIN (US)
HE WEI (US)
LIU KE (US)
HUANG PIN (US)
SUN XIANGYAN (US)
SU JIE (US)
LIU JI (US)
Application Number:
PCT/US2023/028917
Publication Date:
March 14, 2024
Filing Date:
July 28, 2023
Export Citation:
Assignee:
ACCUTAR BIOTECHNOLOGY INC (US)
International Classes:
C07D487/04; C07D253/08; C07D257/10; C07D513/04; A61K31/519; A61P35/00; C07D239/50
Domestic Patent References:
| WO2021231400A1 | 2021-11-18 | |||
| WO2014140989A2 | 2014-09-18 |
Foreign References:
| US20210078977A1 | 2021-03-18 |
Other References:
LATEGAHN JONAS, HARDICK JULIA, GRABE TOBIAS, NIGGENABER JANINA, JEYAKUMAR KIRUJAN, KEUL MARINA, TUMBRINK HANNAH L., BECKER CHRISTI: "Targeting Her2-insYVMA with Covalent Inhibitors—A Focused Compound Screening and Structure-Based Design Approach", JOURNAL OF MEDICINAL CHEMISTRY, vol. 63, no. 20, 22 October 2020 (2020-10-22), US , pages 11725 - 11755, XP093149552, ISSN: 0022-2623, DOI: 10.1021/acs.jmedchem.0c00870
REIERSØLMOEN ANN CHRISTIN; AARHUS THOMAS IHLE; ECKELT SARAH; NØRSETT KRISTIN GABESTAD; SUNDBY EIRIK; HOFF BÅRD HELGE: "Potent and selective EGFR inhibitors based on 5-aryl-7H-pyrrolopyrimidin-4-amines", BIOORGANIC CHEMISTRY, vol. 88, 1 January 2019 (2019-01-01), US , pages 1 - 15, XP085718529, ISSN: 0045-2068, DOI: 10.1016/j.bioorg.2019.102918
REIERSØLMOEN ANN CHRISTIN; AARHUS THOMAS IHLE; ECKELT SARAH; NØRSETT KRISTIN GABESTAD; SUNDBY EIRIK; HOFF BÅRD HELGE: "Potent and selective EGFR inhibitors based on 5-aryl-7H-pyrrolopyrimidin-4-amines", BIOORGANIC CHEMISTRY, vol. 88, 1 January 2019 (2019-01-01), US , pages 1 - 15, XP085718529, ISSN: 0045-2068, DOI: 10.1016/j.bioorg.2019.102918
Attorney, Agent or Firm:
MACALPINE, Jill (US)
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