Title:
HETEROARYLDIHYDROPYRIMIDINE DERIVATIVES AND METHODS OF TREATING HEPATITIS B INFECTIONS
Document Type and Number:
WIPO Patent Application WO/2020/125729
Kind Code:
A1
Abstract:
Provided herein are compounds useful for the treatment of HBV infection in a subject in need thereof, pharmaceutical compositions thereof, and methods of inhibiting, suppressing, or preventing HBV infection in the subject.
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Inventors:
XU YANPING (CN)
JIANG YIMIN (CN)
TU WANGYANG (CN)
DENG GANG (CN)
CHENG ZHANLING (CN)
LIANG CHAO (CN)
JIANG YIMIN (CN)
TU WANGYANG (CN)
DENG GANG (CN)
CHENG ZHANLING (CN)
LIANG CHAO (CN)
Application Number:
PCT/CN2019/126735
Publication Date:
June 25, 2020
Filing Date:
December 19, 2019
Export Citation:
Assignee:
JANSSEN PHARMACEUTICA NV (BE)
JOHNSON & JOHNSON CHINA INVEST LTD (CN)
JOHNSON & JOHNSON CHINA INVEST LTD (CN)
International Classes:
C07D471/04; C07D487/04; C07D498/04; C07D513/04
Domestic Patent References:
| WO2017140750A1 | 2017-08-24 | |||
| WO2016146598A1 | 2016-09-22 | |||
| WO2017076791A1 | 2017-05-11 | |||
| WO2017108630A1 | 2017-06-29 | |||
| WO2018036941A1 | 2018-03-01 | |||
| WO2017064156A1 | 2017-04-20 | |||
| WO2018050571A1 | 2018-03-22 | |||
| WO2015132276A1 | 2015-09-11 | |||
| WO2013102655A1 | 2013-07-11 | |||
| WO1999054326A1 | 1999-10-28 | |||
| WO2017064156A1 | 2017-04-20 | |||
| WO2017140750A1 | 2017-08-24 | |||
| WO2016146598A1 | 2016-09-22 | |||
| WO2017076791A1 | 2017-05-11 | |||
| WO2017108630A1 | 2017-06-29 | |||
| WO2018036941A1 | 2018-03-01 | |||
| WO2017006415A1 | 2017-01-12 | |||
| WO2018050571A1 | 2018-03-22 | |||
| WO2019076310A1 | 2019-04-25 |
Foreign References:
| US20150252057A1 | 2015-09-10 | |||
| US20160083383A1 | 2016-03-24 | |||
| US20150252057A1 | 2015-09-10 | |||
| US20160083383A1 | 2016-03-24 |
Other References:
"Remington's Pharmaceutical Sciences", 1985, MACK PUBLISHING COMPANY, EASTON, pages: 1418
JOURNAL OF PHARMACEUTICAL SCIENCE, vol. 66, 1977, pages 2
HOLFORDSCHEINER, CLIN. PHARMACOKINET, vol. 1, no. 6, 1998, pages 429 - 453
LOEWEMUISCHNEK, ARCH. EXP. PATHOL PHARMACOL, vol. 114, 1926, pages 313 - 326
CHOUTALALAY, ADV. ENZYME REGUL, vol. 22, 1984, pages 27 - 55
J. MED. CHEM., vol. 60, no. 8, 2017, pages 3352 - 3371
SELLSCHENACS, PROC. NATL. ACAD. SCI. USA, vol. 84, 1987, pages 1005 - 1009
See also references of EP 3898628A4
JOURNAL OF PHARMACEUTICAL SCIENCE, vol. 66, 1977, pages 2
HOLFORDSCHEINER, CLIN. PHARMACOKINET, vol. 1, no. 6, 1998, pages 429 - 453
LOEWEMUISCHNEK, ARCH. EXP. PATHOL PHARMACOL, vol. 114, 1926, pages 313 - 326
CHOUTALALAY, ADV. ENZYME REGUL, vol. 22, 1984, pages 27 - 55
J. MED. CHEM., vol. 60, no. 8, 2017, pages 3352 - 3371
SELLSCHENACS, PROC. NATL. ACAD. SCI. USA, vol. 84, 1987, pages 1005 - 1009
See also references of EP 3898628A4
Attorney, Agent or Firm:
NTD UNIVATION INTELLECTUAL PROPERTY AGENCY LTD. (CN)
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