Title:
HETEROCEPHALUS GLABER-DERIVED ANTIMICROBIAL POLYPEPTIDE HAVING POTENT ANTIMICROBIAL ACTIVITY AGAINST GRAM-NEGATIVE BACTERIA AND PHARMACEUTICAL COMPOSITION COMPRISING SAME
Document Type and Number:
WIPO Patent Application WO/2019/039826
Kind Code:
A1
Abstract:
The present invention provides an antimicrobial polypeptide having the amino acid sequence of SEQ ID NO: 1. An antimicrobial polypeptide of the present invention is a novel cathelicidin protein derived from Heterocephalus glaber and can be used as an alternative antibiotic because the protein exhibits potent antimicrobial activity against gram-negative multiple-drug resistant pathogens but is low in cytotoxicity and hemolytic activity.
Inventors:
PARK CHAN KYU (KR)
Application Number:
PCT/KR2018/009577
Publication Date:
February 28, 2019
Filing Date:
August 21, 2018
Export Citation:
Assignee:
KUNKUK UNIV INDUSTRIAL COOPERATION CORP (KR)
International Classes:
C07K14/47; A23K20/147; A23K20/195; A23L3/3463; A61K38/00
Foreign References:
| KR20160118994A | 2016-10-12 |
Other References:
DATABASE Protein 14 March 2015 (2015-03-14), XP055578057, Database accession no. EHB12560.1
DATABASE GenBank 23 May 2017 (2017-05-23), "cathelicidin antimicrobial peptide [Heterocephalus glaber]", XP055578092, Database accession no. XP_004834996.1
ZHANG, L.-J.: "Antimicrobial peptides", CURRENT BIOLOGY, 11 January 2016 (2016-01-11)
CHEN, Y.: "Role of peptide hydrophobicity in the mechanism of action of a-helical antimicrobial peptides", ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, vol. 51, no. 4, April 2007 (2007-04-01), pages 1398 - 1406, XP008149445
WANG, G.: "Structures of human host defense cathelicidin LL-37 and its smallest antimicrobial peptide KR -12 in lipid micelles", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 283, no. 47, 2008, pages 32637 - 23643, XP055577632
LI, X.: "Solution structures of human LL-37 fragments and NMR-based identification of a minimal membrane-targeting antimicrobial and anticancer region", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 128, no. 17, 2006, pages 5776 - 5785, XP002410495
CHO, H.-S.: "The novel cathelicidin of naked mole rats, Hg-CATH, showed potent antimicrobial activity and low cytotoxicity", GENE, vol. 676, 5 July 2018 (2018-07-05), pages 164 - 170, XP055578099
DATABASE GenBank 23 May 2017 (2017-05-23), "cathelicidin antimicrobial peptide [Heterocephalus glaber]", XP055578092, Database accession no. XP_004834996.1
ZHANG, L.-J.: "Antimicrobial peptides", CURRENT BIOLOGY, 11 January 2016 (2016-01-11)
CHEN, Y.: "Role of peptide hydrophobicity in the mechanism of action of a-helical antimicrobial peptides", ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, vol. 51, no. 4, April 2007 (2007-04-01), pages 1398 - 1406, XP008149445
WANG, G.: "Structures of human host defense cathelicidin LL-37 and its smallest antimicrobial peptide KR -12 in lipid micelles", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 283, no. 47, 2008, pages 32637 - 23643, XP055577632
LI, X.: "Solution structures of human LL-37 fragments and NMR-based identification of a minimal membrane-targeting antimicrobial and anticancer region", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 128, no. 17, 2006, pages 5776 - 5785, XP002410495
CHO, H.-S.: "The novel cathelicidin of naked mole rats, Hg-CATH, showed potent antimicrobial activity and low cytotoxicity", GENE, vol. 676, 5 July 2018 (2018-07-05), pages 164 - 170, XP055578099
Attorney, Agent or Firm:
KIM, Jung Su (KR)
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