Title:
HETEROCYCLIC COMPOUND AS TYK2 PSEUDOKINASE DOMAIN INHIBITOR, SYNTHETIC METHOD, AND USE
Document Type and Number:
WIPO Patent Application WO/2022/206705
Kind Code:
A1
Abstract:
The present invention provides a heterocyclic compound as a TYK2 pseudokinase (JH2) domain inhibitor, a synthetic method, and use. In particular, the present invention provides a heterocyclic compound as represented by formula I, or a pharmaceutically acceptable salt thereof, wherein groups are as defined in the text. The heterocyclic compound in the present invention has excellent TYK2 (JH2) selective inhibitory activity.
Inventors:
WANG NENGHUI (CN)
Application Number:
PCT/CN2022/083480
Publication Date:
October 06, 2022
Filing Date:
March 28, 2022
Export Citation:
Assignee:
ZHEJIANG WENDA PHARMA TECH LTD (CN)
International Classes:
C07D213/82; A61K31/444; A61K31/50; A61K31/501; A61P3/10; A61P9/00; A61P11/00; A61P13/12; A61P17/00; A61P17/06; A61P17/10; A61P19/02; A61P25/28; A61P27/02; A61P29/00; A61P35/00; A61P37/02; A61P37/06; A61P43/00; C07D237/24; C07D401/12; C07D403/12
Domestic Patent References:
| WO2020159904A1 | 2020-08-06 |
Foreign References:
| CN104884454A | 2015-09-02 | |||
| CN111315737A | 2020-06-19 | |||
| CN111484480A | 2020-08-04 |
Other References:
RYAN MOSLIN, YANLEI ZHANG, STEPHEN T. WROBLESKI, SHUQUN LIN, MICHAEL MERTZMAN, STEVEN SPERGEL, JOHN S. TOKARSKI, JOANN STRNAD, KAT: "Identification of N -Methyl Nicotinamide and N -Methyl Pyridazine-3-Carboxamide Pseudokinase Domain Ligands as Highly Selective Allosteric Inhibitors of Tyrosine Kinase 2 (TYK2)", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 62, no. 20, 24 October 2019 (2019-10-24), US , pages 8953 - 8972, XP055682301, ISSN: 0022-2623, DOI: 10.1021/acs.jmedchem.9b00443
Attorney, Agent or Firm:
XU&PARTNERS, LLC. (CN)
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