Title:
HETEROCYCLIC COMPOUND DERIVATIVES AND MEDICINES
Document Type and Number:
WIPO Patent Application WO/2002/088084
Kind Code:
A1
Abstract:
The invention provides compounds useful as PGI2 receptor agonist and pharmaceutical compositions, particularly pharmaceutical compositions containing as the active ingredient compounds represented by the general formula (1) or pharmaceutically acceptable salts thereof: (1) wherein R1 and R2 are each independently optionally substituted aryl&semi Y is N, CH, or the like&semi Z is N, CH, or the like&semi A is NH, NR5, O, S, ethylene, or the like&semi R5 is alkyl or the like&semi D is alkylene or alkenylene&semi E is phenylene or a single bond&semi G is O, S, CH2, or the like&semi R3 and R4 are each independently hydrogen or alkyl&semi and Q is carboxyl, alkoxycarbonyl, tetrazolyl, carbamoyl, N−(alkylsulfonyl)carbamoyl, or the like.
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Inventors:
ASAKI TETSUO (JP)
HAMAMOTO TAISUKE (JP)
KUWANO KEIICHI (JP)
HAMAMOTO TAISUKE (JP)
KUWANO KEIICHI (JP)
Application Number:
PCT/JP2002/004118
Publication Date:
November 07, 2002
Filing Date:
April 25, 2002
Export Citation:
Assignee:
NIPPON SHINYAKU CO LTD (JP)
ASAKI TETSUO (JP)
HAMAMOTO TAISUKE (JP)
KUWANO KEIICHI (JP)
ASAKI TETSUO (JP)
HAMAMOTO TAISUKE (JP)
KUWANO KEIICHI (JP)
International Classes:
A61K31/4418; A61K31/4965; A61K31/497; A61K31/505; A61K31/53; A61P3/10; A61P7/02; A61P9/00; A61P9/08; A61P9/10; A61P9/12; A61P11/06; A61P11/08; A61P13/12; A61P17/02; A61P37/02; A61P37/08; A61P43/00; C07D213/74; C07D239/42; C07D241/12; C07D241/18; C07D241/20; C07D253/07; C07D401/04; C07D403/04; C07D409/12; (IPC1-7): C07D213/74; C07D239/42; C07D241/18; C07D241/20; C07D253/06; C07D401/04; C07D403/04; C07D409/12; C07D239/34; C07D239/38; C07D253/07; A61K31/4418; A61K31/4965; A61K31/497; A61K31/505; A61K31/53; A61P3/10; A61P7/02; A61P9/08; A61P9/10; A61P9/12; A61P13/12; A61P43/00; A61P11/06; A61P11/08; A61P9/00; A61P37/02; A61P37/08; A61P17/02
Domestic Patent References:
| WO1992002513A1 | 1992-02-20 |
Foreign References:
| JPH05208961A | 1993-08-20 | |||
| JPH05508845A | 1993-12-09 | |||
| EP0088593A2 | 1983-09-14 | |||
| JPH0733752A | 1995-02-03 |
Other References:
MEANWELL NICHOLAS A. ET AL.: "Nonprostanoid prostacyclin mimetics. 3. Structural variations of the diphenyl heterocycle moiety", J. MED. CHEM., vol. 35, no. 19, 1992, pages 3498 - 3512, XP002196753
KONNO SHOETSU ET AL.: "Studies on as-triazine derivatives. XIX. Synthesis of 2,3-diarylpyrazine and 2,3-diarylpyridine derivatives as blood platelet aggregation inhibitors", YAKUGAKU ZASSHI, vol. 113, no. 1, 1993, pages 40 - 52, XP002955687
BHALLA M. ET AL.: "Synthesis and pharmacological evaluation of 1,2,4-triazine and its congeners", BOLL. CHIM. FARM., vol. 134, no. 1, 1995, pages 9 - 15, XP002955688
See also references of EP 1400518A4
KONNO SHOETSU ET AL.: "Studies on as-triazine derivatives. XIX. Synthesis of 2,3-diarylpyrazine and 2,3-diarylpyridine derivatives as blood platelet aggregation inhibitors", YAKUGAKU ZASSHI, vol. 113, no. 1, 1993, pages 40 - 52, XP002955687
BHALLA M. ET AL.: "Synthesis and pharmacological evaluation of 1,2,4-triazine and its congeners", BOLL. CHIM. FARM., vol. 134, no. 1, 1995, pages 9 - 15, XP002955688
See also references of EP 1400518A4
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