Title:
HETEROCYCLIC COMPOUND, AND INTERMEDIATE THEREOF, PREPARATION METHOD THERFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/166817
Kind Code:
A1
Abstract:
Disclosed are a heterocyclic compound, and an intermediate thereof, a preparation method therefor and the use thereof. Namely, provided are a heterocyclic compound as shown in formula I-a, and a tautomer and a pharmaceutically acceptable salt thereof, wherein the compound has a good water solubility and pharmacokinetic properties.
Inventors:
LI JINPING (CN)
LOU JUN (CN)
WANG ZHANYING (CN)
LIU LI (CN)
GUO XIAODAN (CN)
ZHOU FENG (CN)
ZHANG YIHAN (CN)
CHEN YONGKAI (CN)
WANG CHAODONG (CN)
LOU JUN (CN)
WANG ZHANYING (CN)
LIU LI (CN)
GUO XIAODAN (CN)
ZHOU FENG (CN)
ZHANG YIHAN (CN)
CHEN YONGKAI (CN)
WANG CHAODONG (CN)
Application Number:
PCT/CN2022/074649
Publication Date:
August 11, 2022
Filing Date:
January 28, 2022
Export Citation:
Assignee:
WUHAN LL SCIENCE AND TECH DEVELOPMENT CO LTD (CN)
International Classes:
C07D487/04; A61K31/4985; A61P13/12; A61P25/00
Domestic Patent References:
| WO2019055966A2 | 2019-03-21 | |||
| WO2020061162A1 | 2020-03-26 | |||
| WO2019212937A1 | 2019-11-07 | |||
| WO2019055966A2 | 2019-03-21 |
Foreign References:
| CN202110169176A | 2021-02-07 | |||
| CN202210062324A | 2022-01-19 |
Other References:
NATURE., vol. 451, no. 7174, 3 January 2008 (2008-01-03), pages 69 - 72
MOL PHARMACOL., vol. 73, no. 1, January 2008 (2008-01-01), pages 42 - 9
J BIOL CHEM., vol. 282, no. 46, 16 November 2007 (2007-11-16), pages 33868 - 78
BIOCHEM BIOPHYS RES COMMUN., vol. 365, no. 2, 11 January 2008 (2008-01-11), pages 239 - 45
J BIOL CHEM., vol. 281, no. 44, 3 November 2006 (2006-11-03), pages 33487 - 96
EUR J PHARMACOL., vol. 510, no. 3, 14 March 2005 (2005-03-14), pages 217 - 22
J BIOL CHEM., vol. 281, no. 8, 24 February 2006 (2006-02-24), pages 4977 - 82
BIOCHEM SOC TRANS., vol. 35, February 2007 (2007-02-01), pages 101 - 4
HANDB EXP PHARMACOL., no. 179, 2007, pages 109 - 23
J BIOL CHEM., vol. 280, no. 12, 25 March 2005 (2005-03-25), pages 10997 - 1006
J PHYSIOL, vol. 570, 15 January 2006 (2006-01-15), pages 219 - 35
NAT NEUROSCI, vol. 6, 2003, pages 837 - 45
BERGE ET AL.: "Journal of Pharmaceutical Science", vol. 66, 1977, article "Pharmaceutical Salts", pages: 1 - 19
"Handbook of Pharmaceutical Salts: Properties, Selection, and Use", 2002, WILEY-VCH
RAYMOND C ROWE: "Handbook of Pharmaceutical Excipients", 2020, article "Pharmacopoeia of the People's Republic of China"
MOL PHARMACOL., vol. 73, no. 1, January 2008 (2008-01-01), pages 42 - 9
J BIOL CHEM., vol. 282, no. 46, 16 November 2007 (2007-11-16), pages 33868 - 78
BIOCHEM BIOPHYS RES COMMUN., vol. 365, no. 2, 11 January 2008 (2008-01-11), pages 239 - 45
J BIOL CHEM., vol. 281, no. 44, 3 November 2006 (2006-11-03), pages 33487 - 96
EUR J PHARMACOL., vol. 510, no. 3, 14 March 2005 (2005-03-14), pages 217 - 22
J BIOL CHEM., vol. 281, no. 8, 24 February 2006 (2006-02-24), pages 4977 - 82
BIOCHEM SOC TRANS., vol. 35, February 2007 (2007-02-01), pages 101 - 4
HANDB EXP PHARMACOL., no. 179, 2007, pages 109 - 23
J BIOL CHEM., vol. 280, no. 12, 25 March 2005 (2005-03-25), pages 10997 - 1006
J PHYSIOL, vol. 570, 15 January 2006 (2006-01-15), pages 219 - 35
NAT NEUROSCI, vol. 6, 2003, pages 837 - 45
BERGE ET AL.: "Journal of Pharmaceutical Science", vol. 66, 1977, article "Pharmaceutical Salts", pages: 1 - 19
"Handbook of Pharmaceutical Salts: Properties, Selection, and Use", 2002, WILEY-VCH
RAYMOND C ROWE: "Handbook of Pharmaceutical Excipients", 2020, article "Pharmacopoeia of the People's Republic of China"
Attorney, Agent or Firm:
SHANGHAI BESHINING LAW OFFICE (CN)
Download PDF:
Previous Patent: HINGE AND MOBILE TERMINAL HAVING INFOLDING FLEXIBLE SCREEN
Next Patent: ULTRASOUND ABLATION SYSTEM AND CONTROL METHOD THEREFOR
Next Patent: ULTRASOUND ABLATION SYSTEM AND CONTROL METHOD THEREFOR