Title:
HETEROCYCLIC COMPOUND, PREPARATION METHOD AND USE THEREOF IN MEDICINE
Document Type and Number:
WIPO Patent Application WO/2019/141259
Kind Code:
A1
Abstract:
Provided are a heterocyclic compound, a preparation method and the use thereof in medicine, and particularly involved are a heterocyclic compound for preventing and/or treating hyperuricemia and gout, a preparation method and the use thereof in medicine. In particular, provided are a compound as shown in formula (I) and/or formula (II) or a tautomer thereof and a pharmaceutically acceptable salt thereof, a preparation method therefor and a method and the use thereof for treating hyperuricemia and gout.
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Inventors:
WU YUCHUAN (CN)
CHEN XI (CN)
HUANG SHAOQIANG (CN)
HU YONGHAN (CN)
QU LINHAI (CN)
ZHU JINLIAN (CN)
LIU XIAO (CN)
CHEN XI (CN)
HUANG SHAOQIANG (CN)
HU YONGHAN (CN)
QU LINHAI (CN)
ZHU JINLIAN (CN)
LIU XIAO (CN)
Application Number:
PCT/CN2019/072419
Publication Date:
July 25, 2019
Filing Date:
January 18, 2019
Export Citation:
Assignee:
SUZHOU SINOVENT PHARMA CO LTD (CN)
International Classes:
C07D491/048; A61K31/437; A61K31/498; A61K31/5025; A61P19/06; C07D231/56; C07D401/12; C07D471/04; C07D471/06; C07D473/00
Domestic Patent References:
| WO2012048058A2 | 2012-04-12 | |||
| WO2009145456A2 | 2009-12-03 | |||
| WO2012048058A2 | 2012-04-12 | |||
| WO2006050006A2 | 2006-05-11 |
Foreign References:
| CN106045898A | 2016-10-26 | |||
| CN106432229A | 2017-02-22 | |||
| US4400387A | 1983-08-23 | |||
| CN108084186A | 2018-05-29 | |||
| CN108727267A | 2018-11-02 | |||
| CN106432229A | 2017-02-22 | |||
| CN106045898A | 2016-10-26 | |||
| CN102718735A | 2012-10-10 | |||
| CN106432229A | 2017-02-22 | |||
| EP3543240A1 | 2019-09-25 | |||
| CN108727267A | 2018-11-02 | |||
| US20180282321A1 | 2018-10-04 | |||
| EP3543240A1 | 2019-09-25 |
Other References:
DATABASE CAS 25 June 2015 (2015-06-25), retrieved from STN Database accession no. 918511-73-6
DATABASE CAS 25 June 2015 (2015-06-25), retrieved from STN Database accession no. 870557-88-3
DATABASE CAS 25 June 2015 (2015-06-25), retrieved from STN Database accession no. 14145-68-3
DATABASE CAS 25 June 2015 (2015-06-25), retrieved from STN Database accession no. 102021-88-5
DATABASE CAS 25 June 2015 (2015-06-25), retrieved from STN Database accession no. 15815-29-9
DATABASE CAS 25 June 2015 (2015-06-25), retrieved from STN Database accession no. 885694-11-1
DATABASE CAS 25 June 2015 (2015-06-25), retrieved from STN Database accession no. 1788832-61-0
DATABASE CAS 25 June 2015 (2015-06-25), retrieved from STN Database accession no. 1787965-90-5
DATABASE CAS 25 June 2015 (2015-06-25), retrieved from STN Database accession no. 126521-89-0
DATABASE CAS 25 June 2015 (2015-06-25), retrieved from STN Database accession no. 457943-27-0
DATABASE CAS 25 June 2015 (2015-06-25), retrieved from STN Database accession no. 448198-66-1
DATABASE CAS 25 June 2015 (2015-06-25), retrieved from STN Database accession no. 748087-11-8
DATABASE CAS 25 June 2015 (2015-06-25), retrieved from STN Database accession no. 115407-41-5
DATABASE CAS 25 June 2015 (2015-06-25), retrieved from STN Database accession no. 115407-40-4
DATABASE CAS 25 June 2015 (2015-06-25), retrieved from STN Database accession no. 84855-10-7
THE JOURNAL OF FOOT AND ANKLE SURGERY, vol. 48, no. 1, 2008, pages 70 - 73
CHEM. RES. TOXICOL., vol. 20, no. 12, 2007, pages 1833 - 1842
YUMA KITAGAWA ET AL.: "Novel Bioactuation Pathway of Benzbromone meditated by Cytochrome P450", DRUG METAB DISPOS, vol. 43, September 2015 (2015-09-01), pages 1303 - 1306
SMITH: "March's Advanced Organic Chemistry", 2001, WILEY-INTERSCIENCE, pages: 1218 - 1223
KATRITZKY A.ELGUERO J.: "The Tautromer of Heterocycles", 1976, ACADEMIC PRESS
S.M. BERGE ET AL., J. PHARMA SCI., vol. 66, no. 1, 1977, pages 1 - 19
"Remington: The Science and Practice of Pharmacy", 2005, LIPPINCOTT, WILLIAMS & WILKINS, pages: 732
GREENE, T.W.WUTS, P.G.M.: "Remington: the Science and Practice of Pharmacy", 1995, JOHN WILEY AND SONS
JAAN A. PESTI AND AHMED F. ABDEL-MAGID: "Managing Hazardous Reactions and Compounds in Process Chemistry", 2014, AMERICAN CHEMICAL SOCIETY, article OLIVER R. THIEL, JOHN R. HUCKINS, DEREK B. BROWN, ERIC A. BERCOT, JOHN T. COLYER, BOBBY RIAHI, ROB R. MILBURN, STEVE M. SHAW, AND : "Chapter 11 - Addressing Process Safety Hazards: Replacement of para-Methoxybenzyl ChlorideLeads to a Safer and Shorter Route", XP055830175
M. F. WEMPE, B. QUADE, R JUTABHA, T. IWEN, M. FRICK, R J. RICE, S. WAKUI, AND H. ENDOTI: "HUMAN URIC ACID TRANSPORTER 1 (hURATI): AN INHIBITOR STRUCTURE-ACTIVITY RELATIONSHIP (SAR) STUDY", NUCLEOSIDES, NUCLEOTIDES & NUCLEIC ACIDS, vol. 30, 1 December 2011 (2011-12-01), pages 1312 - 1323, XP055109292
YANG HAO; MURIGI FRANCIS N; WANG ZHIJIAN; LI JUNFENG; JIN HONGJUN; TU ZHUDE: "Synthesis and in vitro characterization of cinnoline and benzimidazole analogues as phosphodiesterase 10A inhibitors", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 25, no. 4, 2014, pages 919 - 924, XP009520968
See also references of EP 3741759A4
DATABASE CAS 25 June 2015 (2015-06-25), retrieved from STN Database accession no. 870557-88-3
DATABASE CAS 25 June 2015 (2015-06-25), retrieved from STN Database accession no. 14145-68-3
DATABASE CAS 25 June 2015 (2015-06-25), retrieved from STN Database accession no. 102021-88-5
DATABASE CAS 25 June 2015 (2015-06-25), retrieved from STN Database accession no. 15815-29-9
DATABASE CAS 25 June 2015 (2015-06-25), retrieved from STN Database accession no. 885694-11-1
DATABASE CAS 25 June 2015 (2015-06-25), retrieved from STN Database accession no. 1788832-61-0
DATABASE CAS 25 June 2015 (2015-06-25), retrieved from STN Database accession no. 1787965-90-5
DATABASE CAS 25 June 2015 (2015-06-25), retrieved from STN Database accession no. 126521-89-0
DATABASE CAS 25 June 2015 (2015-06-25), retrieved from STN Database accession no. 457943-27-0
DATABASE CAS 25 June 2015 (2015-06-25), retrieved from STN Database accession no. 448198-66-1
DATABASE CAS 25 June 2015 (2015-06-25), retrieved from STN Database accession no. 748087-11-8
DATABASE CAS 25 June 2015 (2015-06-25), retrieved from STN Database accession no. 115407-41-5
DATABASE CAS 25 June 2015 (2015-06-25), retrieved from STN Database accession no. 115407-40-4
DATABASE CAS 25 June 2015 (2015-06-25), retrieved from STN Database accession no. 84855-10-7
THE JOURNAL OF FOOT AND ANKLE SURGERY, vol. 48, no. 1, 2008, pages 70 - 73
CHEM. RES. TOXICOL., vol. 20, no. 12, 2007, pages 1833 - 1842
YUMA KITAGAWA ET AL.: "Novel Bioactuation Pathway of Benzbromone meditated by Cytochrome P450", DRUG METAB DISPOS, vol. 43, September 2015 (2015-09-01), pages 1303 - 1306
SMITH: "March's Advanced Organic Chemistry", 2001, WILEY-INTERSCIENCE, pages: 1218 - 1223
KATRITZKY A.ELGUERO J.: "The Tautromer of Heterocycles", 1976, ACADEMIC PRESS
S.M. BERGE ET AL., J. PHARMA SCI., vol. 66, no. 1, 1977, pages 1 - 19
"Remington: The Science and Practice of Pharmacy", 2005, LIPPINCOTT, WILLIAMS & WILKINS, pages: 732
GREENE, T.W.WUTS, P.G.M.: "Remington: the Science and Practice of Pharmacy", 1995, JOHN WILEY AND SONS
JAAN A. PESTI AND AHMED F. ABDEL-MAGID: "Managing Hazardous Reactions and Compounds in Process Chemistry", 2014, AMERICAN CHEMICAL SOCIETY, article OLIVER R. THIEL, JOHN R. HUCKINS, DEREK B. BROWN, ERIC A. BERCOT, JOHN T. COLYER, BOBBY RIAHI, ROB R. MILBURN, STEVE M. SHAW, AND : "Chapter 11 - Addressing Process Safety Hazards: Replacement of para-Methoxybenzyl ChlorideLeads to a Safer and Shorter Route", XP055830175
M. F. WEMPE, B. QUADE, R JUTABHA, T. IWEN, M. FRICK, R J. RICE, S. WAKUI, AND H. ENDOTI: "HUMAN URIC ACID TRANSPORTER 1 (hURATI): AN INHIBITOR STRUCTURE-ACTIVITY RELATIONSHIP (SAR) STUDY", NUCLEOSIDES, NUCLEOTIDES & NUCLEIC ACIDS, vol. 30, 1 December 2011 (2011-12-01), pages 1312 - 1323, XP055109292
YANG HAO; MURIGI FRANCIS N; WANG ZHIJIAN; LI JUNFENG; JIN HONGJUN; TU ZHUDE: "Synthesis and in vitro characterization of cinnoline and benzimidazole analogues as phosphodiesterase 10A inhibitors", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 25, no. 4, 2014, pages 919 - 924, XP009520968
See also references of EP 3741759A4
Attorney, Agent or Firm:
KING & WOOD MALLESONS (CN)
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