HETEROCYCLIC COMPOUND - JAPAN HEALTH SCIENCES FOUND

Title:

HETEROCYCLIC COMPOUND

Document Type and Number:

WIPO Patent Application WO/2018/066545

Kind Code:

A1

Abstract:

Provided is a drug that can decompose a target intracellular protein specifically and is effective for the prevention or treatment of diseases associated with the target protein. An SNIPER compound produced by linking a specific IAP ligand, through a linker, to a ligand capable of specifically binding to a target intracellular protein.

Inventors:

NAITO MIKIHIKO (JP)
OHOKA NOBUMICHI (JP)
SHIBATA NORIHITO (JP)
OKUHIRA KEIICHIRO (JP)
CHO NOBUO (JP)
NAGAI KATSUNORI (JP)
ITO MASAHIRO (JP)
MIYAMOTO NAOKI (JP)
MORITA YOKO (JP)
NARA HIROSHI (JP)
FUJIMORI IKUO (JP)
UJIKAWA OSAMU (JP)
HOMMA MISAKI (JP)
MAEZAKI HIRONOBU (JP)
MORISHITA NAO (JP)
SHIMOKAWA KENICHIRO (JP)

Application Number:

PCT/JP2017/035934

Publication Date:

April 12, 2018

Filing Date:

October 03, 2017

Export Citation:

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Assignee:

JAPAN HEALTH SCIENCES FOUND (JP)

International Classes:

C07K5/062; A61K38/05; A61P35/00; C12N15/09

Domestic Patent References:

WO2008016893A1	2008-02-07
WO2005097791A1	2005-10-20

Foreign References:

JP2013056837A

2013-03-28

Other References:

OKUHIRA, K. ET AL.: "Development of hybrid small molecules that induce degradation of estrogen receptor-alpha and necrotic cell death in breast cancer cells.", CANCER SCIENCE, vol. 104, no. 11, November 2013 (2013-11-01), pages 1492 - 1498, XP055501418
OKUHIRA, K. ET AL.: "Specific degradation of CRABP- II via cIAPl-mediated ubiquitylation induced by hybrid molecules that crosslink cIAP1 and the target protein.", FEBS LETTERS, vol. 585, no. 8, 8 March 2011 (2011-03-08), pages 1147 - 1152, XP028194456
ITOH, Y. ET AL.: "Design, synthesis and biological evaluation of nuclear receptor-degradation inducers", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 19, no. 22, 15 November 2011 (2011-11-15), pages 6768 - 6778, XP028328576
ITOH, Y. ET AL.: "Development of target protein-selective degradation inducer for protein knockdown.", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 19, no. 10, 15 May 2011 (2011-05-15), pages 3229 - 3241, XP028384646
SHIBATA, N. ET AL.: "Development of protein degradation inducers of oncogenic BCR-ABL protein by conjugation of ABL kinase inhibitors and IAP ligands", CANCER SCIENCE, vol. 108, no. 8, August 2017 (2017-08-01), pages 1657 - 1666, XP055501430
SHIBATA, N. ET AL.: "Development of protein degradation inducers of androgen receptor by conjugation of androgen receptor ligands and inhibitor of apoptosis protein ligands.", JOURNAL OF MEDICINAL CHEMISTRY, 23 June 2017 (2017-06-23), XP055501434