Title:
HETEROCYCLIC COMPOUND
Document Type and Number:
WIPO Patent Application WO/2018/143403
Kind Code:
A1
Abstract:
Provided is a novel compound or salt thereof that induces degradation by autophagy of an intracellular molecule. In this compound, a ligand having activity to bind to an intracellular molecule and a structure having activity to induce autophagy of an intracellular molecule are linked via a linker without loss of the activity of the ligand and the structure.
Inventors:
ARIMOTO HIROKAZU (JP)
ITTO KAORI (JP)
TAKAHASHI DAIKI (JP)
CHO NOBUO (JP)
NARA HIROSHI (JP)
SHIMOKAWA KENICHIRO (JP)
OHRA TAIICHI (JP)
SASAKI SHIGEKAZU (JP)
ISHII NAOKI (JP)
ITTO KAORI (JP)
TAKAHASHI DAIKI (JP)
CHO NOBUO (JP)
NARA HIROSHI (JP)
SHIMOKAWA KENICHIRO (JP)
OHRA TAIICHI (JP)
SASAKI SHIGEKAZU (JP)
ISHII NAOKI (JP)
Application Number:
PCT/JP2018/003576
Publication Date:
August 09, 2018
Filing Date:
February 02, 2018
Export Citation:
Assignee:
UNIV TOHOKU (JP)
International Classes:
C07D239/56; A61K31/513; A61K31/52; A61K31/522; A61K31/5517; A61K31/675; A61P35/00; A61P43/00; C07D473/00; C07D473/06; C07D473/08; C07D473/16; C07D473/18; C07D473/30; C07D473/34; C07D519/00; C07H19/213; C12N5/09; C07D487/14; C07D495/14
Domestic Patent References:
| WO2012087336A1 | 2012-06-28 | |||
| WO2008122038A1 | 2008-10-09 | |||
| WO2012088254A1 | 2012-06-28 | |||
| WO2016119856A1 | 2016-08-04 | |||
| WO2013155223A1 | 2013-10-17 | |||
| WO2014152588A1 | 2014-09-25 | |||
| WO2015054572A1 | 2015-04-16 | |||
| WO2016049524A1 | 2016-03-31 |
Other References:
CZLAPINSKI, J. L. ET AL.: "Conditional Glycosylation in Eukaryotic Cells Using a Biocompatible Chemical Inducer of Dimerization", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 130, no. 40, 2008, pages 13186 - 13187, XP055037681, ISSN: 0002-7863
ERHART, D. ET AL.: "Chemical Development of Intracellular Protein Heterodimerizers", CHEMISTRY & BIOLOGY, vol. 20, no. 4, 2013, Oxford, United Kingdom, pages 549 - 557, XP055530533, ISSN: 1074-5521
ZIMMERMANN, M. ET AL.: "Cell-Permeant and Photocleavable Chemical Inducer of Dimerization", CELL-PERMEANT AND PHOTOCLEAVABLE CHEMICAL INDUCER OF DIMERIZATION, vol. 53, no. 18, 2014, pages 4717 - 4720, XP055295966, ISSN: 1433-7851
FENG,S. ET AL.: "A Rapidly Reversible Chemical Dimerizer System to Study Lipid Signaling in Living Cells", ANGEWANDTE CHEMIE , INTERNATIONAL EDITION, vol. 53, no. 26, 2014, pages 6720 - 6723, XP055530540, ISSN: 1433-7851
MOL. CELL, vol. 52, 2013, pages 794 - 804
"master's thesis", 4 February 2015, TOHOKU UNIVERSITY, article "Role of S-guanylation in selective autophagy"
NATURE, vol. 503, 2013, pages 548 - 551
SCIENCE, vol. 351, 2016, pages 604 - 608
NAT. REV. DRUG DISCOV., vol. 13, 2014, pages 828 - 851
CHEM. SOC. REV., 2016
L. F. TIETZETH. EICHER: "Modern Organic Synthesis in the Laboratory: A Collection of Standard Experimental Procedures", vol. I-VII, 1989, KAGAKU-DOJIN PUBLISHING COMPANY, INC.
THEODORA W. GREENEPETER G. M. WUTS: "Protective Groups in Organic Synthesis", 2007, WILEY-INTERSCIENCE
P.J. KOCIENSKI: "Protecting Groups", 2004, THIEME MEDICAL PUBLISHERS
XLA, ACS CHEMICAL BIOLOGY, vol. 10, no. 11, 2015, pages 2441 - 2447
"Molecular Design", vol. 7, 1990, HIROKAWA SHOTEN LTD., article "Iyakuhin No Kaihatsu (Development of Pharmaceuticals in English", pages: 163 - 198
BIOTECHNIQUES, vol. 47, 2009, pages 769 - 774
NATURE, vol. 468, 2010, pages 1067 - 1073
See also references of EP 3578549A4
ERHART, D. ET AL.: "Chemical Development of Intracellular Protein Heterodimerizers", CHEMISTRY & BIOLOGY, vol. 20, no. 4, 2013, Oxford, United Kingdom, pages 549 - 557, XP055530533, ISSN: 1074-5521
ZIMMERMANN, M. ET AL.: "Cell-Permeant and Photocleavable Chemical Inducer of Dimerization", CELL-PERMEANT AND PHOTOCLEAVABLE CHEMICAL INDUCER OF DIMERIZATION, vol. 53, no. 18, 2014, pages 4717 - 4720, XP055295966, ISSN: 1433-7851
FENG,S. ET AL.: "A Rapidly Reversible Chemical Dimerizer System to Study Lipid Signaling in Living Cells", ANGEWANDTE CHEMIE , INTERNATIONAL EDITION, vol. 53, no. 26, 2014, pages 6720 - 6723, XP055530540, ISSN: 1433-7851
MOL. CELL, vol. 52, 2013, pages 794 - 804
"master's thesis", 4 February 2015, TOHOKU UNIVERSITY, article "Role of S-guanylation in selective autophagy"
NATURE, vol. 503, 2013, pages 548 - 551
SCIENCE, vol. 351, 2016, pages 604 - 608
NAT. REV. DRUG DISCOV., vol. 13, 2014, pages 828 - 851
CHEM. SOC. REV., 2016
L. F. TIETZETH. EICHER: "Modern Organic Synthesis in the Laboratory: A Collection of Standard Experimental Procedures", vol. I-VII, 1989, KAGAKU-DOJIN PUBLISHING COMPANY, INC.
THEODORA W. GREENEPETER G. M. WUTS: "Protective Groups in Organic Synthesis", 2007, WILEY-INTERSCIENCE
P.J. KOCIENSKI: "Protecting Groups", 2004, THIEME MEDICAL PUBLISHERS
XLA, ACS CHEMICAL BIOLOGY, vol. 10, no. 11, 2015, pages 2441 - 2447
"Molecular Design", vol. 7, 1990, HIROKAWA SHOTEN LTD., article "Iyakuhin No Kaihatsu (Development of Pharmaceuticals in English", pages: 163 - 198
BIOTECHNIQUES, vol. 47, 2009, pages 769 - 774
NATURE, vol. 468, 2010, pages 1067 - 1073
See also references of EP 3578549A4
Attorney, Agent or Firm:
ASAMURA PATENT OFFICE, P.C. (JP)
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