Title:
HETEROCYCLIC COMPOUND
Document Type and Number:
WIPO Patent Application WO/2019/069844
Kind Code:
A1
Abstract:
Provided is a compound or salt thereof that may have excellent JAK inhibitory action and that may be useful as an agent for preventing or treating an autoimmune disease (rheumatoid arthritis, psoriasis, inflammatory bowel disease, Sjogren's syndrome, Behcet's disease, multiple sclerosis, systemic lupus erythematosus, or the like), cancer (leukemia, uterine leiomyosarcoma, prostate cancer, multiple myeloma, cachexia, myelofibrosis, and the like), or the like. The present invention relates to a compound represented by formula (I) (In formula (I), the reference symbols are as defined in the specification.), or a salt thereof.
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Inventors:
HANYA YUKI (JP)
ICHIKAWA TAKASHI (JP)
NEGORO NOBUYUKI (JP)
YOSHIKAWA TAKESHI (JP)
FUKUDA HIROMI (JP)
IMAEDA TOSHIHIRO (JP)
KAIEDA AKIRA (JP)
OYABU NORIO (JP)
SHIOKAWA ZENYU (JP)
KIKUCHI FUMIAKI (JP)
KAWASAKI MASANORI (JP)
ICHIKAWA TAKASHI (JP)
NEGORO NOBUYUKI (JP)
YOSHIKAWA TAKESHI (JP)
FUKUDA HIROMI (JP)
IMAEDA TOSHIHIRO (JP)
KAIEDA AKIRA (JP)
OYABU NORIO (JP)
SHIOKAWA ZENYU (JP)
KIKUCHI FUMIAKI (JP)
KAWASAKI MASANORI (JP)
Application Number:
PCT/JP2018/036660
Publication Date:
April 11, 2019
Filing Date:
October 01, 2018
Export Citation:
Assignee:
TAKEDA PHARMACEUTICALS CO (JP)
International Classes:
C07D495/04; A61K31/4439; A61K31/496; A61P1/04; A61P17/00; A61P17/06; A61P19/02; A61P29/00; A61P35/00; A61P35/02; A61P37/02; A61P43/00
Domestic Patent References:
| WO2007056155A1 | 2007-05-18 |
Foreign References:
| JP2016537384A | 2016-12-01 | |||
| JP2014501724A | 2014-01-23 | |||
| GB2480815A | 2011-12-07 | |||
| JP2017518339A | 2017-07-06 |
Other References:
SIMOV, V. ET AL.: "Structure-based design and development of (benz) imidazole pyridones as JAK1-selective kinase inhibitors", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 26, no. 7, 19 February 2016 (2016-02-19), pages 1803 - 1808, XP029453936, DOI: doi:10.1016/j.bmcl.2016.02.035
NOZAKI, MASAKATSU ET AL.,: "Medical Chemistry", 1 July 1995 (1995-07-01), pages 98 - 99
NOZAKI, MASAKATSU ET AL.,: "Medical Chemistry", 1 July 1995 (1995-07-01), pages 98 - 99
Attorney, Agent or Firm:
TAKASHIMA, Hajime et al. (JP)
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