Title:
HETEROCYCLIC COMPOUND
Document Type and Number:
WIPO Patent Application WO/2020/122093
Kind Code:
A1
Abstract:
The present invention provides a heterocyclic compound that has orexin 2 receptor agonist activity. Compounds represented by formula (I) and salts thereof have orexin 2 receptor agonist activity and are useful as agents for the prevention or treatment of narcolepsy. (The symbols in formula (I) are as defined in the description.)
Inventors:
KAJITA YUICHI (JP)
MIYANOHANA YUHEI (JP)
KOIKE TATSUKI (JP)
HOASHI YASUTAKA (JP)
HATTORI YASUSHI (JP)
TOKUNAGA NORIHITO (JP)
ODA TSUNEO (JP)
MIYAZAKI TOHRU (JP)
AINIWAER DILIHUMAER (JP)
ITO YOSHITERU (JP)
TAKEUCHI KOHEI (JP)
IMAMURA KEISUKE (JP)
SUGIMOTO TAKAHIRO (JP)
FUKUDA KOICHIRO (JP)
KOHARA YASUHISA (JP)
OKAMOTO REI (JP)
OHRA TAIICHI (JP)
MIYAMOTO NAOKI (JP)
TERAO YOSHITO (JP)
KAWASAKI MASANORI (JP)
MIYANOHANA YUHEI (JP)
KOIKE TATSUKI (JP)
HOASHI YASUTAKA (JP)
HATTORI YASUSHI (JP)
TOKUNAGA NORIHITO (JP)
ODA TSUNEO (JP)
MIYAZAKI TOHRU (JP)
AINIWAER DILIHUMAER (JP)
ITO YOSHITERU (JP)
TAKEUCHI KOHEI (JP)
IMAMURA KEISUKE (JP)
SUGIMOTO TAKAHIRO (JP)
FUKUDA KOICHIRO (JP)
KOHARA YASUHISA (JP)
OKAMOTO REI (JP)
OHRA TAIICHI (JP)
MIYAMOTO NAOKI (JP)
TERAO YOSHITO (JP)
KAWASAKI MASANORI (JP)
Application Number:
PCT/JP2019/048385
Publication Date:
June 18, 2020
Filing Date:
December 11, 2019
Export Citation:
Assignee:
TAKEDA PHARMACEUTICALS CO (JP)
International Classes:
C07D215/38; A61K31/416; A61K31/428; A61K31/437; A61K31/47; A61K31/506; A61P25/20; A61P43/00; C07D231/54; C07D401/14; C07D471/04
Domestic Patent References:
| WO2017135306A1 | 2017-08-10 | |||
| WO2020004536A1 | 2020-01-02 | |||
| WO2020004537A1 | 2020-01-02 | |||
| WO2019027003A1 | 2019-02-07 | |||
| WO2015073707A1 | 2015-05-21 | |||
| WO2015048091A1 | 2015-04-02 | |||
| WO2015147240A1 | 2015-10-01 | |||
| WO2012137982A9 | 2013-02-14 | |||
| WO2017135306A1 | 2017-08-10 | |||
| WO2018164191A1 | 2018-09-13 | |||
| WO2018164192A1 | 2018-09-13 | |||
| WO2019027003A1 | 2019-02-07 | |||
| WO2019027058A1 | 2019-02-07 | |||
| WO2001000663A2 | 2001-01-04 | |||
| WO2011051433A2 | 2011-05-05 | |||
| WO2015000852A1 | 2015-01-08 |
Foreign References:
| JP2014523851A | 2014-09-18 | |||
| US20190040010A1 | 2019-02-07 | |||
| JP2018232993A | 2018-12-12 |
Other References:
CELL, vol. 92, 1998, pages 573 - 585
CELL, vol. 98, 1999, pages 437 - 451
PROC. NATL. ACAD. SCI. USA, vol. 101, 2004, pages 4649 - 4654
NEURON, vol. 38, 2003, pages 715 - 730
CNS DRUGS, vol. 27, 2013, pages 83 - 90
CELL METABOLISM, vol. 9, 2009, pages 64 - 76
NEUROSCIENCE, vol. 121, 2003, pages 855 - 863
RESPIRATION, vol. 71, 2004, pages 575 - 579
PEPTIDES, vol. 23, 2002, pages 1683 - 1688
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY., vol. 66, 2015, pages 2522 - 2533
BRAIN, vol. 130, 2007, pages 1586 - 1595
L. F. TIETZETH. EICHERNANKODO, FINE ORGANIC CHEMISTRY, vol. 14-15
HIDEO TOGOKODANSHA, ORGANIC NAME REACTIONS, THE REACTION MECHANISM AND ESSENCE
KIYOSHI TOMIOKAKAGAKUDOJIN: "Modern Organic Synthesis in the Laboratory A Collection of Standard Experimental Procedures", vol. 1 - Vol.14, 1989, JOHN WILEY & SONS INC.
THEODORA W. GREENEPETER G. M. WUTS: "Protective Groups in Organic Synthesis", 2007, WILEY-INTERSCIENCE, INC.
P.J. KOCIENSKI: "Protecting Groups 3rd Ed.", 2004, THIEME
IYAKUHINKAIHATSU: "Design of Molecules", vol. 7, 1990, HIROKAWA SHOTEN, article "Development of Pharmaceuticals", pages: 163 - 198
BIOCHEM. J., vol. 340, no. 1, 1999, pages 283 - 289
See also references of EP 3896060A4
CELL, vol. 98, 1999, pages 437 - 451
PROC. NATL. ACAD. SCI. USA, vol. 101, 2004, pages 4649 - 4654
NEURON, vol. 38, 2003, pages 715 - 730
CNS DRUGS, vol. 27, 2013, pages 83 - 90
CELL METABOLISM, vol. 9, 2009, pages 64 - 76
NEUROSCIENCE, vol. 121, 2003, pages 855 - 863
RESPIRATION, vol. 71, 2004, pages 575 - 579
PEPTIDES, vol. 23, 2002, pages 1683 - 1688
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY., vol. 66, 2015, pages 2522 - 2533
BRAIN, vol. 130, 2007, pages 1586 - 1595
L. F. TIETZETH. EICHERNANKODO, FINE ORGANIC CHEMISTRY, vol. 14-15
HIDEO TOGOKODANSHA, ORGANIC NAME REACTIONS, THE REACTION MECHANISM AND ESSENCE
KIYOSHI TOMIOKAKAGAKUDOJIN: "Modern Organic Synthesis in the Laboratory A Collection of Standard Experimental Procedures", vol. 1 - Vol.14, 1989, JOHN WILEY & SONS INC.
THEODORA W. GREENEPETER G. M. WUTS: "Protective Groups in Organic Synthesis", 2007, WILEY-INTERSCIENCE, INC.
P.J. KOCIENSKI: "Protecting Groups 3rd Ed.", 2004, THIEME
IYAKUHINKAIHATSU: "Design of Molecules", vol. 7, 1990, HIROKAWA SHOTEN, article "Development of Pharmaceuticals", pages: 163 - 198
BIOCHEM. J., vol. 340, no. 1, 1999, pages 283 - 289
See also references of EP 3896060A4
Attorney, Agent or Firm:
TAKASHIMA, Hajime (JP)
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