Title:
HETEROCYCLIC COMPOUND
Document Type and Number:
WIPO Patent Application WO/2021/020362
Kind Code:
A1
Abstract:
Provided is a compound which has a glucosylceramide synthase-inhibiting activity and is expected to be useful as a prophylactic or therapeutic agent for a lysosomal storage disease (e.g., Gaucher disease, Fabry disease, GM1-gangliosidosis, GM2 activation factor deficiency disease, Tay–Sachs disease, Sandhoff disease), a neurodegenerative disease (e.g., Parkinson's disease, dementia with Lewy bodies, multiple system atrophy) and the like. The present invention relates to a compound represented by formula (I) [wherein each symbol is as described in the description] or a salt thereof.
Inventors:
TANAKA YUTA (JP)
TANAKA YUTA (JP)
KAKEGAWA KEIKO (JP)
KASAHARA TAKAHITO (JP)
KIKUCHI FUMIAKI (JP)
YAMAMOTO TAKESHI (JP)
OHASHI TOMOHIRO (JP)
IKEDA ZENICHI (JP)
PUENNER FLORIAN (JP)
NAKAMURA MINORU (JP)
TAKAMI KAZUAKI (JP)
MURAKAMI MASATAKA (JP)
DAINI MASAKI (JP)
SETO MASAKI (JP)
MIKAMI SATOSHI (JP)
SASAKI MINORU (JP)
TANAKA YUTA (JP)
KAKEGAWA KEIKO (JP)
KASAHARA TAKAHITO (JP)
KIKUCHI FUMIAKI (JP)
YAMAMOTO TAKESHI (JP)
OHASHI TOMOHIRO (JP)
IKEDA ZENICHI (JP)
PUENNER FLORIAN (JP)
NAKAMURA MINORU (JP)
TAKAMI KAZUAKI (JP)
MURAKAMI MASATAKA (JP)
DAINI MASAKI (JP)
SETO MASAKI (JP)
MIKAMI SATOSHI (JP)
SASAKI MINORU (JP)
Application Number:
PCT/JP2020/028784
Publication Date:
February 04, 2021
Filing Date:
July 28, 2020
Export Citation:
Assignee:
TAKEDA PHARMACEUTICALS CO (JP)
International Classes:
A61P25/16; A61K31/4412; A61K31/443; A61K31/4439; A61K31/444; A61K31/497; A61K31/50; A61K31/501; A61K31/505; A61K31/506; A61K31/5377; A61P25/28; A61P39/02; A61P43/00; C07D213/82; C07D213/84; C07D213/85; C07D237/24; C07D239/36; C07D401/12; C07D401/14; C07D405/12; C07D405/14; C07D413/12; C07D471/04
Domestic Patent References:
| WO2015068767A1 | 2015-05-14 | |||
| WO2019151269A1 | 2019-08-08 |
Foreign References:
| JP2019510043A | 2019-04-11 | |||
| JP2019516744A | 2019-06-20 | |||
| JP2009529047A | 2009-08-13 | |||
| JP5463033B2 | 2014-04-09 | |||
| JP2018520109A | 2018-07-26 | |||
| US20160361301A1 | 2016-12-15 | |||
| US20150210681A1 | 2015-07-30 | |||
| US8445509B2 | 2013-05-21 | |||
| US20050288290A1 | 2005-12-29 | |||
| US7439246B2 | 2008-10-21 | |||
| US20060004006A1 | 2006-01-05 | |||
| JP2019139174A | 2019-08-22 |
Other References:
BRAIN RES BULL, vol. 24, pages 131 - 141
ANN CLIN TRANSL NEUROL, vol. 2, no. 4, April 2015 (2015-04-01), pages 433 - 438
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 114, no. 10, 2017, pages 2699 - 2704
L. F. TIETZETH. EICHER, NANKODO: "Modern Organic Synthesis in the Laboratory A Collection of Standard Experimental Procedures", vol. I-VII, 1989, THE CHEMICAL SOCIETY OF JAPAN, pages: 14 - 15
THEODORA W. GREENEPETER G. M. WUTS: "Protective Groups in Organic Synthesis", 2007, WILEY-INTERSCIENCE, INC
P.J. KOCIENSKI: "Protecting Groups", 2004, THIEME
"Shin Jikken Kagaku Kouza", vol. 19, 1990, CHEMICAL SOCIETY OF JAPAN, article "Development of Pharmaceutical Products", pages: 163 - 198
See also references of EP 4005637A4
ANN CLIN TRANSL NEUROL, vol. 2, no. 4, April 2015 (2015-04-01), pages 433 - 438
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 114, no. 10, 2017, pages 2699 - 2704
L. F. TIETZETH. EICHER, NANKODO: "Modern Organic Synthesis in the Laboratory A Collection of Standard Experimental Procedures", vol. I-VII, 1989, THE CHEMICAL SOCIETY OF JAPAN, pages: 14 - 15
THEODORA W. GREENEPETER G. M. WUTS: "Protective Groups in Organic Synthesis", 2007, WILEY-INTERSCIENCE, INC
P.J. KOCIENSKI: "Protecting Groups", 2004, THIEME
"Shin Jikken Kagaku Kouza", vol. 19, 1990, CHEMICAL SOCIETY OF JAPAN, article "Development of Pharmaceutical Products", pages: 163 - 198
See also references of EP 4005637A4
Attorney, Agent or Firm:
TAKASHIMA, Hajime (JP)
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