Title:
HETEROCYCLIC COMPOUND
Document Type and Number:
WIPO Patent Application WO/2021/075476
Kind Code:
A1
Abstract:
Provided is a compound which has an effect of inhibiting neuron degeneration, in particular, an effect of inhibiting motor neuron degeneration and which is useful as a prophylactic or therapeutic agent for motor neuron diseases (for example, amyotrophic lateral sclerosis, progressive bulbar paralysis, progressive muscular atrophy, primary lateral sclerosis, progressive pseudobulbar paralysis, spinal muscular atrophy, Parkinson's disease, Lewy body dementia, multiple system atrophy and Friedreich's ataxia), etc. The present invention pertains to a compound represented by formula (I) [wherein each symbol is as defined in the description] or a salt thereof.
Inventors:
TOYOFUKU MASASHI (JP)
ITO YOSHITERU (JP)
PIRA MARILENA (JP)
SUGIMOTO TAKAHIRO (JP)
ITO YOSHITERU (JP)
PIRA MARILENA (JP)
SUGIMOTO TAKAHIRO (JP)
Application Number:
PCT/JP2020/038850
Publication Date:
April 22, 2021
Filing Date:
October 15, 2020
Export Citation:
Assignee:
TAKEDA PHARMACEUTICALS CO (JP)
International Classes:
A61P25/02; A61K31/416; A61K31/437; A61K31/5365; C07D231/56; C07D405/12; C07D487/04; C07D498/04
Domestic Patent References:
| WO2016114322A1 | 2016-07-21 | |||
| WO2017014170A1 | 2017-01-26 | |||
| WO2016114322A1 | 2016-07-21 | |||
| WO2012029994A1 | 2012-03-08 |
Foreign References:
| JP2010536846A | 2010-12-02 | |||
| JP2018524378A | 2018-08-30 | |||
| JP2017533957A | 2017-11-16 | |||
| EP2489663A1 | 2012-08-22 | |||
| JP2019191533A | 2019-10-31 |
Other References:
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G. R. SMITH ET AL., JOURNAL OF MOLECULAR NEUROSCIENCE, vol. 52, 2014, pages 446 - 458
W. FISCHER ET AL., REDOX BIOLOGY, vol. 21, 2019, pages 101089
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N. EGAWA ET AL., SCIENCE TRANSLATIONAL MEDICINE, vol. 4, 2012
K. IMAMURA ET AL., SCIENCE TRANSLATIONAL MEDICINE, vol. 9, 2017, pages eaaf3962
K. FUJIMORI ET AL., NATURE MEDICINE, vol. 24, 2018, pages 1579 - 1589
M. G. COTTICELLI ET AL., J PHARMACOL EXP THER, vol. 369, 2019, pages 47 - 54
SHIN JIKKEN KAGAKU KOUZA, vol. 14-15
L. F. TIETZETH. EICHERNANKODO, FINE ORGANIC CHEMISTRY
HIDEO TOGO, KODANSHA: "ORGANIC SYNTHESES Collective", vol. I-VII, JOHN WILEY & SONS INC., article "Organic Name Reactions, the Reaction Mechanism and Essence, Revised Edition"
KIYOSHI TOMIOKA, KAGAKUDOJIN: "Modern Organic Synthesis in the Laboratory A Collection of Standard Experimental Procedures", vol. 1-14, 1989, VCH PUBLISHERS INC., article "Strategic Applications of Named Reactions in Organic Synthesis"
THEODORA W. GREENEPETER G. M. WUTS: "Protective Groups in Organic Synthesis, 4th Ed", 2007, WILEY-INTERSCIENCE, INC.
P.J. KOCIENSKI: "Protecting Groups 3rd Ed.", 2004, THIEME
"Shin Jikken Kagaku Kouza", vol. 19, 1990, HIROKAWA SHOTEN, article "Development of Pharmaceutical Products", pages: 163 - 198
T. V. BERGHE ET AL., NATURE REVIEWS MOLECULAR CELL BIOLOGY, vol. 15, 2014, pages 135 - 147
Z. LIA ET AL., EUROPEAN JOURNAL OF PHARMACOLOGY, vol. 844, 2019, pages 156 - 164
K. W. LI ET AL., JOURNAL OF NEUROCHEMISTRY, 2018
N. J. ASHTON ET AL., ACTA NEUROPATHOLOGICA COMMUNICATIONS, vol. 7, 2019, pages 5
G. R. SMITH ET AL., JOURNAL OF MOLECULAR NEUROSCIENCE, vol. 52, 2014, pages 446 - 458
W. FISCHER ET AL., REDOX BIOLOGY, vol. 21, 2019, pages 101089
Y. SHI ET AL., NATURE REVIEWS DRUG DISCOVERY, vol. 16, 2017, pages 115 - 130
A. E. MICHAEL ET AL., LANCET, vol. 390, 2017, pages 2085 - 2098
N. EGAWA ET AL., SCIENCE TRANSLATIONAL MEDICINE, vol. 4, 2012
K. IMAMURA ET AL., SCIENCE TRANSLATIONAL MEDICINE, vol. 9, 2017, pages eaaf3962
K. FUJIMORI ET AL., NATURE MEDICINE, vol. 24, 2018, pages 1579 - 1589
M. G. COTTICELLI ET AL., J PHARMACOL EXP THER, vol. 369, 2019, pages 47 - 54
SHIN JIKKEN KAGAKU KOUZA, vol. 14-15
L. F. TIETZETH. EICHERNANKODO, FINE ORGANIC CHEMISTRY
HIDEO TOGO, KODANSHA: "ORGANIC SYNTHESES Collective", vol. I-VII, JOHN WILEY & SONS INC., article "Organic Name Reactions, the Reaction Mechanism and Essence, Revised Edition"
KIYOSHI TOMIOKA, KAGAKUDOJIN: "Modern Organic Synthesis in the Laboratory A Collection of Standard Experimental Procedures", vol. 1-14, 1989, VCH PUBLISHERS INC., article "Strategic Applications of Named Reactions in Organic Synthesis"
THEODORA W. GREENEPETER G. M. WUTS: "Protective Groups in Organic Synthesis, 4th Ed", 2007, WILEY-INTERSCIENCE, INC.
P.J. KOCIENSKI: "Protecting Groups 3rd Ed.", 2004, THIEME
"Shin Jikken Kagaku Kouza", vol. 19, 1990, HIROKAWA SHOTEN, article "Development of Pharmaceutical Products", pages: 163 - 198
Attorney, Agent or Firm:
TAKASHIMA, Hajime (JP)
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