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Title:
HETEROCYCLIC COMPOUNDS AS KRAS INHIBITOR, AND PREPARATION THEREFOR AND USE THEREOF IN TREATMENT
Document Type and Number:
WIPO Patent Application WO/2022/247760
Kind Code:
A1
Abstract:
Disclosed are compounds of formulae (I) and (II) or a pharmaceutically acceptable salt, a prodrug, a tautomer or a stereoisomer thereof and a solvate thereof; and a method for preparing the compounds of formulae (I) and (II), and a pharmaceutical composition containing the compounds. The compounds can be used for treating cancer and inflammation in mammals.

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Inventors:
TIAN HONGQI (CN)
HUANG GONGCHAO (CN)
GAO XUGUANG (CN)
ZHAO TUAN (CN)
XU HAIJIANG (CN)
MA WEIMIN (CN)
LIU HUANHUAN (CN)
WANG XINGKAI (CN)
Application Number:
PCT/CN2022/094300
Publication Date:
December 01, 2022
Filing Date:
May 22, 2022
Export Citation:
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Assignee:
SHANGHAI KECHOW PHARMA INC (CN)
International Classes:
C07D471/04; A61K31/4375; A61K31/4709; A61K31/496; A61K31/517; A61K31/519; A61P35/00; C07D401/06; C07D401/14; C07D403/14; C07D409/14; C07D487/04; C07D519/00
Domestic Patent References:
WO2022068921A12022-04-07
WO2022042630A12022-03-03
WO2022098625A12022-05-12
WO2022066646A12022-03-31
WO2021190467A12021-09-30
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Foreign References:
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Other References:
WANG XIAOLUN, ALLEN SHELLEY, BLAKE JAMES F., BOWCUT VICKIE, BRIERE DAVID M., CALINISAN ANDREW, DAHLKE JOSHUA R., FELL JAY B., FISC: "Identification of MRTX1133, a Noncovalent, Potent, and Selective KRAS G12D Inhibitor", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 65, no. 4, 24 February 2022 (2022-02-24), US , pages 3123 - 3133, XP055952002, ISSN: 0022-2623, DOI: 10.1021/acs.jmedchem.1c01688
Attorney, Agent or Firm:
WU, FENG & ZHANG (CN)
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