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Title:
HETEROCYCLIC COMPOUNDS, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH
Document Type and Number:
WIPO Patent Application WO/2024/008179
Kind Code:
A1
Abstract:
Provided herein are compounds having the following structure: wherein the substituents are as defined herein, compositions comprising an effective amount of a compound, and methods for modulating activity of KRAS G12D.

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Inventors:
WANG CE (CN)
YU CHAO (CN)
YUAN HAO (CN)
LI XIAOYU (CN)
WANG ZHIWEI (CN)
SUN HANZI (CN)
Application Number:
PCT/CN2023/106299
Publication Date:
January 11, 2024
Filing Date:
July 07, 2023
Export Citation:
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Assignee:
BEIGENE LTD (GB)
WANG CE (CN)
International Classes:
C07D471/04; A61K31/4375; A61P35/00; C07D401/14; C07D519/00
Domestic Patent References:
WO2023018699A12023-02-16
WO2022171147A12022-08-18
WO2022177917A22022-08-25
WO2022261154A12022-12-15
WO2022148422A12022-07-14
WO2022184178A12022-09-09
WO2022173870A12022-08-18
WO2022266206A12022-12-22
WO2023072188A12023-05-04
WO2022047260A12022-03-03
WO2021041671A12021-03-04
Foreign References:
CN115490709A2022-12-20
Attorney, Agent or Firm:
WU, FENG & ZHANG (CN)
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