Title:
HETEROCYCLIC COMPOUNDS HAVING NOS INHIBITORY ACTIVITIES
Document Type and Number:
WIPO Patent Application WO/1999/023069
Kind Code:
A1
Abstract:
Compounds represented by general formula (1), having NOS inhibitory activities, and being useful as medicines such as a remedy for cerebrovascular disorder, wherein R¿1? represents aminoalkyl, etc.; R¿2? represents hydrogen, lower alkyl, etc.; R¿3? represents SR¿4? (wherein R¿4?) represents lower alkyl, etc.), etc.; and Ar represents a five-membered heteroaryl group, etc.
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| WO/2001/032602 | DIARYL-ENYNES |
| JPH07225401 | NONLINEAR OPTICAL MATERIAL |
| WO/1994/008943 | 2-AMINO-1,3-PROPANEDIOL COMPOUND AND IMMUNOSUPPRESSANT |
Inventors:
MAKINO TOSHIHIKO (JP)
Application Number:
PCT/JP1998/004967
Publication Date:
May 14, 1999
Filing Date:
November 04, 1998
Export Citation:
Assignee:
CHUGAI PHARMACEUTICAL CO LTD (JP)
MAKINO TOSHIHIKO (JP)
MAKINO TOSHIHIKO (JP)
International Classes:
C07D207/325; C07D207/335; C07D231/12; C07D249/08; C07D521/00; C07D207/32; (IPC1-7): C07D207/325; A61K31/40; A61K31/41; A61K31/415; C07D231/12; C07D249/08
Domestic Patent References:
| WO1997036860A1 | 1997-10-09 |
Foreign References:
| JPH0665222A | 1994-03-08 | |||
| US5668159A | 1997-09-16 | |||
| JPS57120575A | 1982-07-27 |
Other References:
FERRONI R, ET AL.: "GUANIDINOPHENYL DERIVATIVES OF PYRAZOLE: SYNTHESIS AND INHIBITORY EFFECT ON SERINE PROTEINASES BLOOD COAGULATION AND PLATELET AGGREGATION", FARMACO, EDIZIONE SCIENTIFICA., SOCIETA CHIMICA ITALIANA, PAVIA., IT, vol. 41, no. 10, 1 January 1986 (1986-01-01), IT, pages 747 - 757, XP002920029, ISSN: 0430-0920
See also references of EP 1043312A4
See also references of EP 1043312A4
Attorney, Agent or Firm:
Shamoto, Ichio (New Ohtemachi Building 2-1, Ohtemachi 2-chome Chiyoda-ku Tokyo, JP)
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