Title:
HETEROCYCLIC COMPOUNDS INHIBITING ANGIOGENESIS
Document Type and Number:
WIPO Patent Application WO2001009113
Kind Code:
A3
Abstract:
The invention relates to compounds of general formula (I) wherein R stands for a group of general formula -COOR<1>, -CONR<2>R<3>, -CONR<4>CONR<4>R<5> or -CH2OR<6>, wherein R<1> stands for a C2-6 alkyl group; a C1-6 alkyl group substituted; or a C3-6 cycloalkyl group; R<2> and R<3> are identical or different and stand independently from each other for hydrogen atom or a C1-6 alkyl group which optionally may be substituted; a 5- or 6-membered cycloalkyl or a heteroaryl group; and their tautomers, solvates and the mixtures thereof and acid addition salts of these compounds. The invention also relates to pharmaceutical compositions comprising compounds of general formula (I) as active agent. The angiogenesis-inhibitors according to the invention inhibit the neovascularisation in living tissues and as such can be used for preventing and inhibiting angiogenesis appearing in connection with tumour growth and for preventing the formation of tumour metastases.
Inventors:
MAKK NANDOR (HU)
AMBRUS GABOR (HU)
TEGDES ANIKO (HU)
JENEY ANDRAS (HU)
TIMAR FERENC (HU)
AMBRUS GABOR (HU)
TEGDES ANIKO (HU)
JENEY ANDRAS (HU)
TIMAR FERENC (HU)
Application Number:
PCT/HU2000/000088
Publication Date:
June 14, 2001
Filing Date:
August 02, 2000
Export Citation:
Assignee:
GYOGYSZERKUTATO INTEZET (HU)
MAKK NANDOR (HU)
AMBRUS GABOR (HU)
TEGDES ANIKO (HU)
JENEY ANDRAS (HU)
TIMAR FERENC (HU)
MAKK NANDOR (HU)
AMBRUS GABOR (HU)
TEGDES ANIKO (HU)
JENEY ANDRAS (HU)
TIMAR FERENC (HU)
International Classes:
A61K31/335; A61K31/34; A61K31/4427; A61K31/5377; A61P17/06; A61P19/02; A61P27/02; A61P35/00; A61P35/04; A61P43/00; C07D313/00; C07D405/12; C07D407/12; (IPC1-7): C07D313/00; C07D405/12; A61K31/335; A61P35/00
Other References:
PATENT ABSTRACTS OF JAPAN vol. 1996, no. 11 29 November 1996 (1996-11-29)
PATENT ABSTRACTS OF JAPAN vol. 1998, no. 01 30 January 1998 (1998-01-30)
WAKABAYASHI, TOSHIAKI ET AL: "Borrelidin is an angiogenesis inhibitor;disruption of angiogenic capillary vessels in a rat aorta matrix culture model", J. ANTIBIOT. (1997), 50(8), 671-676, XP002158986
KELLER-SCHIERLEIN W.: "Stoffwechselprodukte von Mikroorganismen Über die Konstitution des Borrelidins", HELVETICA CHIMICA ACTA., vol. 50, no. 3, 1967, VERLAG HELVETICA CHIMICA ACTA. BASEL., CH, pages 731 - 753, XP002158987, ISSN: 0018-019X
PATENT ABSTRACTS OF JAPAN vol. 1998, no. 01 30 January 1998 (1998-01-30)
WAKABAYASHI, TOSHIAKI ET AL: "Borrelidin is an angiogenesis inhibitor;disruption of angiogenic capillary vessels in a rat aorta matrix culture model", J. ANTIBIOT. (1997), 50(8), 671-676, XP002158986
KELLER-SCHIERLEIN W.: "Stoffwechselprodukte von Mikroorganismen Über die Konstitution des Borrelidins", HELVETICA CHIMICA ACTA., vol. 50, no. 3, 1967, VERLAG HELVETICA CHIMICA ACTA. BASEL., CH, pages 731 - 753, XP002158987, ISSN: 0018-019X
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