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Title:
HETEROCYCLIC COMPOUNDS AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/1999/021839
Kind Code:
A1
Abstract:
Novel remedies or preventives for frequent urination or urinary incontinence which are superior in usefulness to the existing drugs. Specifically, heterocyclic compounds represented by the following general formula (1): Ar¿1?-X-(CH¿2?)m-B or pharmacologically acceptable thereof which are useful as remedies or preventives for frequent urination or urinary incontinence, and remedies or preventives as described above which contain the same as the active ingredient, wherein Ar represents optionally substituted phenyl, indanyl, naphthyl or tetrahydronaphthyl; X represents -C(OH)R¿1?-CR¿2?R¿3?- or -CR¿1?=CR¿3?- (wherein R¿1? represents hydrogen, lower alkyl, cycloalkyl or optionally substituted phenyl; and R¿2? and R¿3? are the same or different and each represents hydrogen or lower alkyl); m is an integer of 1 or 2; and B represents an optionally substituted heterocycle.

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Inventors:
KOGA ICHIRO (JP)
OKADA ATSUSHI (JP)
NARITA KAZUHISA (JP)
Application Number:
PCT/JP1998/004807
Publication Date:
May 06, 1999
Filing Date:
October 23, 1998
Export Citation:
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Assignee:
NIPPON KAYAKU KK (JP)
KOGA ICHIRO (JP)
OKADA ATSUSHI (JP)
NARITA KAZUHISA (JP)
International Classes:
C07D233/54; C07D233/60; (IPC1-7): C07D233/60; A61K31/415
Domestic Patent References:
WO1998037070A11998-08-27
WO1996031208A21996-10-10
WO1998000140A11998-01-08
WO1998000141A11998-01-08
Foreign References:
JPS55162777A1980-12-18
JPH07508514A1995-09-21
JPH06336431A1994-12-06
JPH07215943A1995-08-15
Other References:
Chemical Abstracts Service (C A S); 1 January 1976 (1976-01-01), BEDDARD G S, CARLIN S E, LEWIS C: "INTERACTION OF AROMATIC AMINE EXCIPLEXES WITH POLAR MOLECULES", XP002918420
Attorney, Agent or Firm:
Saeki, Norio (Nihonbashi 3-chome Chuo-ku Tokyo, JP)
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