HETEROCYCLIC COMPOUNDS USEFUL AS INHIBITORS OF TYROSINE KINASES

Title:

HETEROCYCLIC COMPOUNDS USEFUL AS INHIBITORS OF TYROSINE KINASES

Document Type and Number:

WIPO Patent Application WO2002014319

Kind Code:

A3

Abstract:

Disclosed are novel compounds of formula (I) (see formula I as described in specification) wherein Ar1, X, Y, P, Q and Het are defined herein, which are useful as inhibitors of certain protein tyrosine kinases and are thus useful for treating diseases resulting from inappropriate cell proliferation, which include autoimmune diseases, chronic inflammatory diseases, allergic diseases, transplant rejection and cancer, as well as conditions resulting from cerebral ischemia, such as stroke. Also disclosed are pharmaceutical compositions comprising these compounds, processes for preparing these compounds and novel intermediate compounds useful in these processes.

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Inventors:

SNOW ROGER JOHN
GAO DONGHONG A
GOLDBERG DANIEL R
HAMMACH ABDELHAKIM
KUZMICH DANIEL
MORWICK TINA MARIE
MOSS NEIL
PROKOPOWICZ III ANTHONY S
SELLIAH ROBERT D
TAKAHASHI HIDENORI

Application Number:

PCT/US2001/024390

Publication Date:

August 01, 2002

Filing Date:

August 02, 2001

Export Citation:

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Assignee:

BOEHRINGER INGELHEIM PHARMA (US)

International Classes:

A61K31/517; A61P1/04; A61P3/10; A61P9/00; A61P9/10; A61P11/06; A61P17/06; A61P19/02; A61P19/08; A61P25/00; A61P35/00; A61P37/02; A61P37/06; A61P43/00; C07D487/04; (IPC1-7): C07D487/04; A61K31/505

Domestic Patent References:

WO1999024035A1	1999-05-20
WO1998028281A1	1998-07-02

Foreign References:

EP0322746A1	1989-07-05
US4176184A	1979-11-27

Other References:

DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; KUMAR, SHIV ET AL: "Possible anthelmintic agents: syntheses of various imidazoquinazolinone carbamates", XP002190316, retrieved from STN Database accession no. 97:38906
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; AGARWAL, SHIV K. ET AL: "Segregation of activity profile in benzimidazoles: effect of spacers at 5(6)-position of methyl benzimidazole-2-carbamates", XP002190317, retrieved from STN Database accession no. 120:124172

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