Title:
HETEROCYCLIC DERIVATIVE, PREPARATION METHOD THEREFOR, AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/169391
Kind Code:
A1
Abstract:
The present invention relates to a heterocyclic derivative, a preparation method therefor, a pharmaceutical composition containing the derivative, and an application thereof in medicine. Specifically, the present invention relates to a heterocyclic derivative represented by general formula (I), a preparation method therefor and a pharmaceutically acceptable salt thereof, as well as to the use of the above as therapeutic agents, especially as RAC1 inhibitors, wherein the definitions of each substituent in general formula (I) are the same as the definitions in the description.
Inventors:
WU NUOYI (CN)
CHEN YOUXI (CN)
WU CHENGFEI (CN)
YE CHENG (CN)
XU DAIWANG (CN)
XU XIAOJIE (CN)
CHEN YOUXI (CN)
WU CHENGFEI (CN)
YE CHENG (CN)
XU DAIWANG (CN)
XU XIAOJIE (CN)
Application Number:
PCT/CN2023/079984
Publication Date:
September 14, 2023
Filing Date:
March 07, 2023
Export Citation:
Assignee:
ZHEJIANG HISUN PHARM CO LTD (CN)
SHANGHAI ARYL PHARMTECH CO LTD (CN)
SHANGHAI ARYL PHARMTECH CO LTD (CN)
International Classes:
C07D215/36; A61P35/00; C07D401/12; C07D413/14
Domestic Patent References:
| WO2019023315A2 | 2019-01-31 | |||
| WO2007034329A2 | 2007-03-29 |
Foreign References:
| CN104592132A | 2015-05-06 |
Other References:
DATABASE Registry 16 February 2017 (2017-02-16), ANONYMOUS : "Quinoline, 4-[[5-[4-(1-piperazinylmethyl)phenoxy]pentyl]thio]-7- (trifluoromethyl)- (CA INDEX NAME)", XP093090035, retrieved from STNext Database accession no. 921753-40-4
WAN ZHIHUA, HU DEYU, LI PEI, XIE DANDAN, GAN XIUHAI: "Synthesis, Antiviral Bioactivity of Novel 4-Thioquinazoline Derivatives Containing Chalcone Moiety", MOLECULES, vol. 20, no. 7, 29 June 2015 (2015-06-29), pages 11861 - 11874, XP093090033, DOI: 10.3390/molecules200711861
WAN ZHIHUA, HU DEYU, LI PEI, XIE DANDAN, GAN XIUHAI: "Synthesis, Antiviral Bioactivity of Novel 4-Thioquinazoline Derivatives Containing Chalcone Moiety", MOLECULES, vol. 20, no. 7, 29 June 2015 (2015-06-29), pages 11861 - 11874, XP093090033, DOI: 10.3390/molecules200711861
Attorney, Agent or Firm:
SINO-CREATIVITY INTELLECTUAL PROPERTY LAW FIRM (CN)
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