Title:
HETEROCYCLIC DERIVATIVES AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2019/231271
Kind Code:
A1
Abstract:
The present invention relates to novel heterocyclic compounds useful in preparing drugs for the prevention or treatment of diseases associated with STAT3 protein. Specifically, these drugs are useful in the prevention or treatment of solid tumors, blood cancers, radiation or drug-resistant cancers, metastatic cancers, inflammatory diseases, immune system diseases, diabetes, macular degeneration, papillomavirus infections and tuberculosis.
Inventors:
PARK CHAN HEE (KR)
IM JUN HWAN (KR)
LEE SOON OK (KR)
LEE SANG HWI (KR)
KO KWANG SEOK (KR)
KIM BYUNG HO (KR)
MOON HYUNG JO (KR)
KIM JAE ILL (KR)
PARK HEON KYU (KR)
HONG YEON JU (KR)
IM JUN HWAN (KR)
LEE SOON OK (KR)
LEE SANG HWI (KR)
KO KWANG SEOK (KR)
KIM BYUNG HO (KR)
MOON HYUNG JO (KR)
KIM JAE ILL (KR)
PARK HEON KYU (KR)
HONG YEON JU (KR)
Application Number:
PCT/KR2019/006554
Publication Date:
December 05, 2019
Filing Date:
May 31, 2019
Export Citation:
Assignee:
C&C RES LAB (KR)
International Classes:
C07D215/38; A61K31/47; A61K31/502; A61K31/517; A61K31/53; A61P31/06; A61P35/00; A61P37/00
Domestic Patent References:
| WO2014145512A2 | 2014-09-18 | |||
| WO2009007422A1 | 2009-01-15 | |||
| WO2005061516A1 | 2005-07-07 | |||
| WO2014145512A2 | 2014-09-18 | |||
| WO2009007422A1 | 2009-01-15 | |||
| WO2005061516A1 | 2005-07-07 | |||
| WO2012079079A1 | 2012-06-14 | |||
| WO2010093419A1 | 2010-08-19 | |||
| WO2010036629A2 | 2010-04-01 | |||
| WO2008086462A2 | 2008-07-17 | |||
| WO2019046778A1 | 2019-03-07 |
Foreign References:
| US20100234324A1 | 2010-09-16 | |||
| US20110172429A1 | 2011-07-14 | |||
| US20100234324A1 | 2010-09-16 | |||
| US20110172429A1 | 2011-07-14 |
Other References:
BECKER S ET AL., NATURE, 1998, pages 394
VINKEMEIER U ET AL., SCIENCE, 1998, pages 279
CHEN X ET AL., CELL, 1998, pages 93
D. NECULAI ET AL., J. BIOL. CHEM., 2005, pages 280
SCHINDLER C ET AL., ANNU. REV. BIOCHEM., 1995, pages 64
NOVICK D ET AL., CELL, 1994, pages 76
HO AS ET AL., PROC. NATL. ACAD. SCI., 1993, pages 90
STARK ET AL., ANNU. REV. BIOCHEM., 1997, pages 67
LEVY ET AL., NAT. REV. MOL. CELL BIOL., 2002, pages 3
ZHONG ET AL., SCIENCE, 1994, pages 264
MASUDA ET AL., CANCER RES., 2002, pages 62
BENEKLI ET AL., BLOOD, 2002, pages 99
YUICHI ET AL., INT. J. ONCOLOGY, 2007, pages 30
AKIRA ET AL., ONCOGENE, 2000, pages 19
VALERIA POLI ET AL., REVIEW, LANDES BIOSCIENCE, 2009
SIDDIQUEE ET AL., PROC. NATL. ACAD. SCI., 2007, pages 104
SIDDIQUEE ET AL., CHEM. BIOL., 2007, pages 2
LIN ET AL., NEOPLASIA, 2010, pages 12
SCHUST ET AL., CHEM. BIOL., 2006, pages 13
SONG ET AL., PROC. NATL. ACAD. SCI., 2005, pages 102
ZHANG ET AL., BIOCHEM. PHARM., 2010, pages 79
MATSUNO ET AL., ACS MED. CHEM. LETT., 2010, pages 1
TURKSON J ET AL., MOL CANCER THER., 2004, pages 261
COLEMAN ET AL., J. MED. CHEM., 2005, pages 48
See also references of EP 3802495A4
VINKEMEIER U ET AL., SCIENCE, 1998, pages 279
CHEN X ET AL., CELL, 1998, pages 93
D. NECULAI ET AL., J. BIOL. CHEM., 2005, pages 280
SCHINDLER C ET AL., ANNU. REV. BIOCHEM., 1995, pages 64
NOVICK D ET AL., CELL, 1994, pages 76
HO AS ET AL., PROC. NATL. ACAD. SCI., 1993, pages 90
STARK ET AL., ANNU. REV. BIOCHEM., 1997, pages 67
LEVY ET AL., NAT. REV. MOL. CELL BIOL., 2002, pages 3
ZHONG ET AL., SCIENCE, 1994, pages 264
MASUDA ET AL., CANCER RES., 2002, pages 62
BENEKLI ET AL., BLOOD, 2002, pages 99
YUICHI ET AL., INT. J. ONCOLOGY, 2007, pages 30
AKIRA ET AL., ONCOGENE, 2000, pages 19
VALERIA POLI ET AL., REVIEW, LANDES BIOSCIENCE, 2009
SIDDIQUEE ET AL., PROC. NATL. ACAD. SCI., 2007, pages 104
SIDDIQUEE ET AL., CHEM. BIOL., 2007, pages 2
LIN ET AL., NEOPLASIA, 2010, pages 12
SCHUST ET AL., CHEM. BIOL., 2006, pages 13
SONG ET AL., PROC. NATL. ACAD. SCI., 2005, pages 102
ZHANG ET AL., BIOCHEM. PHARM., 2010, pages 79
MATSUNO ET AL., ACS MED. CHEM. LETT., 2010, pages 1
TURKSON J ET AL., MOL CANCER THER., 2004, pages 261
COLEMAN ET AL., J. MED. CHEM., 2005, pages 48
See also references of EP 3802495A4
Attorney, Agent or Firm:
HANSUNG INTELLECTUAL PROPERTY (KR)
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